Results 31 to 40 of about 25,482,573 (239)

Overview of meta‐analysis

Ibrain, 2021
Meta‐analysis has been recognized as the best means to evaluate objectively and study the evidence for a particular issue. In order to give researchers a better understanding of the Meta process, we present an overall introduction to Meta‐analysis in ...
Xu Fang, Nan Zhao, Zhao‐Qiong Zhu
doaj   +1 more source

Misleading meta-analysis [PDF]

BMJ, 1995
A meta-analysis of treatments in myocardial infarction published in 1992 retrospectively showed that streptokinase was associated with a highly significant fall in mortality by 1977, after inclusion of 15 trials.1 Thrombolysis was, however, not widely recommended until 10 years later—after the effect was confirmed in two mega trials.1 2 3 In the case ...
M, Egger, G D, Smith
openaire   +3 more sources

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Nature Genetics, 2013
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained.
J. Lambert, C. Ibrahim-Verbaas, D. Harold, A. Naj, R. Sims, C. Bellenguez, G. Jun, A. Destefano, J. Bis, G. Beecham, B. Grenier‐Boley, G. Russo, T. Thornton-Wells, N. Jones, A. Smith, V. Chouraki, C. Thomas, M. Ikram, D. Zélénika, B. Vardarajan, Y. Kamatani, Chiao-Feng Lin, A. Gerrish, H. Schmidt, B. Kunkle, M. Dunstan, A. Ruiz, M. Bihoreau, S. Choi, C. Reitz, F. Pasquier, P. Hollingworth, A. Ramírez, O. Hanon, A. Fitzpatrick, J. Buxbaum, D. Campion, P. Crane, C. Baldwin, T. Becker, V. Gudnason, C. Cruchaga, D. Craig, N. Amin, C. Berr, O. Lopez, P. Jager, V. Deramecourt, J. Johnston, D. Evans, S. Lovestone, L. Letenneur, F. Morón, D. Rubinsztein, G. Eiriksdottir, K. Sleegers, A. Goate, N. Fievet, M. Huentelman, M. Gill, K. Brown, M. Kamboh, L. Keller, P. Barberger‐Gateau, B. McGuinness, E. Larson, R. Green, A. Myers, C. Dufouil, S. Todd, D. Wallon, S. Love, E. Rogaeva, J. Gallacher, P. George-Hyslop, J. Clarimón, A. Lleó, A. Bayer, D. Tsuang, Lei Yu, M. Tsolaki, P. Bossù, G. Spalletta, P. Proitsi, J. Collinge, S. Sorbi, F. Sánchez-García, Nick C Fox, J. Hardy, M. Naranjo, P. Bosco, R. Clarke, C. Brayne, D. Galimberti, M. Mancuso, F. Matthews, S. Moebus, P. Mecocci, M. Zompo, W. Maier, H. Hampel, A. Pilotto, M. Bullido, F. Panza, P. Caffarra, B. Nacmias, J. Gilbert, M. Mayhaus, L. Lannfelt, H. Hakonarson, S. Pichler, M. Carrasquillo, M. Ingelsson, D. Beekly, V. Álvarez, F. Zou, O. Valladares, S. Younkin, E. Coto, K. Hamilton-Nelson, W. Gu, C. Razquín, P. Pastor, I. Mateo, M. Owen, K. Faber, P. Jonsson, O. Combarros, M. O’Donovan, L. Cantwell, H. Soininen, D. Blacker, S. Mead, T. Mosley, D. Bennett, T. Harris, L. Fratiglioni, C. Holmes, R. F. Bruijn, P. Passmore, T. Montine, K. Bettens, J. Rotter, A. Brice, K. Morgan, T. Foroud, W. Kukull, D. Hannequin, J. Powell, M. Nalls, K. Ritchie, K. Lunetta, J. Kauwe, E. Boerwinkle, M. Riemenschneider, M. Boada, M. Hiltunen, E. Martin, R. Schmidt, D. Rujescu, Li-San Wang, J. Dartigues, R. Mayeux, C. Tzourio, A. Hofman, M. Nöthen, C. Graff, B. Psaty, L. Jones, J. Haines, P. Holmans, M. Lathrop, M. Pericak-Vance, L. Launer, L. Farrer, C. Duijn, C. Broeckhoven, V. Moskvina, S. Seshadri, Julie Williams, G. Schellenberg, P. Amouyel   +181 more
semanticscholar   +1 more source

Results of the Childhood Cancer and Leukaemia Group's United Kingdom Relapsed Wilms Tumour Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The United Kingdom relapsed Wilms tumour (UKW‐R) trial aimed to improve the historically low survival rates after relapse of Wilms tumour (WT) through a prospective national risk‐stratified protocol. The trial also evaluated efficacy and toxicity of high‐dose melphalan.
Sucheta J. Vaidya, Veronica Moroz, Juliet Hale, Vesna Pavasovic, Rachel Hobson, Patricia Sartori, Daniel Saunders, Mark Powis, Gordan M. Vujanic, Stephen Baker, Kathy Pritchard‐Jones   +10 more
wiley   +1 more source

Prognostic role of EZH2 in gliomas: a meta-analysis

The International Journal of Biological Markers, 2018
Background: The aim of this study was to elucidate the clinicopathological significance of enhancer of zeste homolog 2 (EZH2) expression in gliomas, including its incidence and prognostic role.
Jung-Soo Pyo, Dong-Wook Kang
doaj   +1 more source

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Cardiovascular risk factors, global cardiovascular risk, and vascular age in a cohort of Peruvian HIV patients

HIV & AIDS Review. International Journal of HIV-Related Problems
Introduction Data on cardiovascular risk and vascular age in patients with human immunodeficiency virus (HIV) from developing countries are scarce. Therefore, the current study aimed to determine the prevalence of cardiovascular risk factors, global ...
German Valenzuela-Rodriguez, Jaime A. Collins, Raul Castillo, Luis R. Illescas, Adrian V. Hernandez, Carlos Diaz-Arocutipa   +5 more
doaj   +1 more source

Meta-analyses in psychology often overestimate evidence for and size of effects

Royal Society Open Science, 2023
Adjusting for publication bias is essential when drawing meta-analytic inferences. However, most methods that adjust for publication bias do not perform well across a range of research conditions, such as the degree of heterogeneity in effect sizes ...
František Bartoš, Maximilian Maier, David R. Shanks, T. D. Stanley, Martina Sladekova, Eric-Jan Wagenmakers   +5 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Effectiveness of non-technical skills training in intensive care units: a systematic review

BMC Medical Education
Background Non-technical skills (NTS) are social, cognitive and psychological skills that are related to safety and efficiency in the healthcare process. These skills have an important role in the intensive care once are closely related to the occurrence
Isac Davidson Santiago Fernandes Pimenta, Ádala Nayana de Sousa Mata, Isaac Newton Machado Bezerra, Rícia Medeiros Palmeira de Araújo, Jorge Lucas Alves Santana, Helaine Carneiro Capucho, Adriana Catarina de Souza-Oliveira, Paloma Echevarría-Pérez, Daniel Guillén-Martínez, Grasiela Piuvezam   +9 more
doaj   +1 more source