Results 191 to 200 of about 239,752 (297)

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Advanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao   +27 more
wiley   +1 more source

The conclusiveness of trial sequential analysis varies with estimation of between-study variance: a case study. [PDF]

BMC Med Res Methodol
Kang E, Hodges JS, Chuang YC, Chen JH, Chen C, Cochrane Taiwan.   +5 more
europepmc   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Prophylactic Interventions for Heel Pressure Ulcers in Critically Ill Patients Admitted to an Intensive Care Unit: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Koyanagi M, Sakuramoto H, Kajiwara K, Fukushima A, Yoshihara S, Mukoyama M, Horinouchi M, Mihara A, Imamura Y.   +8 more
europepmc   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Geriatric assessment domains as predictors for clinical endpoints in older adults with cancer: Protocol for an updated systematic review. [PDF]

PLoS One
Sattar S, Papadopoulos E, Haase KR, Bradley C, Mariano C, Tejero I, Jin R, Puts M, Alibhai SMH.   +8 more
europepmc   +1 more source

AlphaFold‐Guided Bespoke Gene Editing Enhances Field‐Grown Soybean Oil Contents

Advanced Science, EarlyView.
An AlphaFold‐guided method is developed to functionally optimize soybean sugar transporters and achieve bespoke gene editing of GmSWEET10a/b to improve oil content in an elite soybean cultivar in multi‐year, multi‐site field trials. The combination of AI‐guided protein design and gene editing may unlock a huge potential to improve the genetic trait de ...
Jie Wang, Li Zhang, Shoudong Wang, Xin Wang, Suning Li, Pingping Gong, Mengyan Bai, Arnav Paul, Nathan Tvedt, Hengrui Ren, Maoxiang Yang, Zhihui Zhang, Shaodong Zhou, Jiayi Sun, Xianjin Wu, Huaqin Kuang, Zhenghua Du, Yonghui Dong, Xiaolei Shi, Meina Li, Diwakar Shukla, Long Yan, Yuefeng Guan   +22 more
wiley   +1 more source

Assessing Transitivity, Inconsistencies, and Transparency in Network Comparisons for Novel Therapies in Worsening Heart Failure. [PDF]

JACC Adv
Queiroz I, Barbosa LM, Gallo Ruelas M.
europepmc   +1 more source

Robustly Repeatable, Permeable, and Multi‐Axially Stretchable, Adhesive Bioelectronics With Super‐adaptive Conductive Suction Cups for Continuously Deformable Biosurfaces

Advanced Science, EarlyView.
It is presented bioelectronics that exhibit exceptional adaptability to dynamic skin surfaces through an integrated structural and material design. These omnidirectionally stretchable, skin‐compliant, mechanically robust, and permeably biocompatible kirigami‐based devices minimize skin irritation and conductivity loss and offer new insights for the ...
Gyun Ro Kang, Gui Won Hwang, Dohyun Lim, Seung Hwan Jeon, Minwoo Song, Chan‐Hwa Hong, Hye Jin Kim, Changhyun Pang   +7 more
wiley   +1 more source

Editorial: Insights in obstetrics and gynecology: 2023. [PDF]

Front Med (Lausanne)
Cohen SM, Yagel S.
europepmc   +1 more source