Results 201 to 210 of about 62,271,634 (307)

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Thermal Control of Concentric Topographies Patterned by Dynamic Electro‐Templated Generated Chiral Solitonic Structures

Advanced Science, EarlyView.
An electro‐templating strategy directs the relaxation of cholesteric finger loops into discrete concentric rings whose geometry is electrically programmed. The photopolymerized structures retain the topological defect pattern and, upon heating, show reversible, castle‐like surface modulation.
Jacques A. Peixoto, Hanqing Zhao, Dirk J. Broer, Ivan I. Smalyukh, Danqing Liu   +4 more
wiley   +1 more source

Association between Chagas disease and the occurrence of stroke: systematic review with meta-analysis. [PDF]

Cad Saude Publica
Santos ACJ, Benitez JFD, Baldoni NR, Ferreira AM, Silva JLPD, Nunes MDCP, Ribeiro ALP, Sabino EC, Haikal DS.   +8 more
europepmc   +1 more source

Topical ruxolitinib vs topical roflumilast for itch reduction in atopic dermatitis: A comparative meta-analysis

Journal of the American Academy of Dermatology
Grace Xiong, Sana Gupta, Vinesh Rao, Mohannad Abu-Hilal   +3 more
openaire   +2 more sources

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

A methodological framework for conducting diagnostic meta-analyses using large literature corpora. [PDF]

BMC Med Res Methodol
Portilla-Yela J, Tovar-Cuevas JR.
europepmc   +1 more source

Electrochemically Driven Regioselective Radical Functionalization of Allenes: Scope and Mechanistic Insights

Advanced Science, EarlyView.
Allenes emerge as powerful platforms for electrochemical functionalization through radical pathways. Selective radical addition at the central carbon triggers anodic oxidation and intramolecular cyclization, enabling efficient synthesis of oxazolines and oxazolidine‐2‐imines without external oxidants.
Pranjal Pyne, Prateek Saini, Rohel Hoque, Shivam Pandey, Srinivasan Ramakrishnan, Chandra M. R. Volla   +5 more
wiley   +1 more source

Global inequities in representation of low-income and middle-income countries in vaccine clinical trials: protocol for a systematic review and meta-epidemiological analysis. [PDF]

BMJ Open
Ramalan M, Yusuf I, Mathew M, Bako I, Imam MU, Musa B.   +5 more
europepmc   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Comparative evaluation of artificial intelligence-assisted literature search tools for identifying clinically meaningful evidence in cardiology. [PDF]

Eur Heart J Digit Health
Di Febo R, Jeanneret Medina M, Renaud A, Dridi M, Pecriaux V, Lequeux B, Lafitte S, Maille B, Menet A.   +8 more
europepmc   +1 more source