Results 51 to 60 of about 846,990 (265)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo   +5 more
wiley   +1 more source

A conceptual approach to meta-modelling [PDF]

open access: yes, 1997
In this paper we propose a conceptual-based approach to meta-modelling as a technique in which modelling knowledge can be expressed. Our approach claims to be sufficiently flexible and to homogenize the construction of meta-models, independently of the field of application.
Eladio Domínguez   +2 more
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Development of a meta-model for the determination of technological value of cotton fiber using design of experiments and the TOPSIS method

open access: yesJournal of Natural Fibers, 2018
To meet the requirements of the cotton spinning industry and achieve the best quality of ring-spun yarn, it becomes an imperative task to determine the technological values of cotton fibers. The availability of High Volume Instrument (HIV) data now makes
Prasenjit Chatterjee   +1 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

META-MODELING CONSTRUCTS FOR REQUIREMENTS REUSE (RR): SOFTWARE REQUIREMENTS PATTERNS, VARIABILITY AND TRACEABILITY

open access: yesMalaysian Journal of Computing, 2018
Reuse is a fundamental activity, which increases quality and productivity of software products. Reuse of software artifacts, such as requirements, architectures, and codes can be employed at any developmental stage of software. However, reuse at a higher
Badamasi Imam Ya’u, Azlin Nordin, Norsaremah Salleh
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Optimization and Experimental Verification of Lower Articulation for Low-Floor Tram Using Meta-Model

open access: yesApplied Sciences
This study aimed to optimize the lower articulation of low-floor trams using a meta-model technique, followed by an experimental validation. The design variables were identified through structural analyses, and the optimization reduced the weight of the ...
Ji-Won Jin   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy