Results 71 to 80 of about 597,495 (286)

Effect-Size Discrepancies in Literature Versus Raw Datasets from Experimental Spinal Cord Injury Studies: A CLIMBER Meta-Analysis

Neurotrauma Reports
Translation of spinal cord injury (SCI) therapeutics from pre-clinical animal studies into human studies is challenged by effect size variability, irreproducibility, and misalignment of evidence used by pre-clinical versus clinical literature.
Emma G. Iorio, Alireza Khanteymoori, Kenneth A. Fond, Anastasia V. Keller, Lex Maliga Davis, Jan M. Schwab, Adam R. Ferguson, Abel Torres-Espin, Ralf Watzlawick   +8 more
doaj   +1 more source

The sceptical chemist and the unwise philosopher : inaugural lecture delivered at Rhodes University [PDF]

, 1960
Inaugural lecture delivered at Rhodes UniversityRhodes University Libraries ...
Oosthuizen, D.C.S. (Daniel Charl Stephanus)
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Replication marketplaces would help science to become more self-correcting

Royal Society Open Science
Independent replications are very rare in the behavioural and social sciences. This is problematic because they can help to detect ‘false positives’ in published research and, in turn, contribute to scientific self-correction.
Joachim Hüffmeier, Clara Kühner
doaj   +1 more source

How Education Drives Demography and Knowledge Informs Projections [PDF]

, 2013
This paper makes the case for systematically adding education to age and sex as a third standard demographic dimension. It directly addresses the question whether the pervasive association of education with demographic outcomes reflects a causal ...
Lutz, W., Skirbekk, V.
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Some data indicating that editors and reviewers do not check preregistrations during the review process

Journal of Trial and Error
If a study is preregistered, but nobody checks it during review, does it mean anything? The purpose of this preregistered study was to better understand how editors and reviewers engage with preregistration plans during the review process.
Moin Syed
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic?

BMC Medicine, 2018
Introduction Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are critical to inform decision-making by patients, clinicians and policy-makers in real-world settings.
Rafael Dal-Ré, Perrine Janiaud, John P. A. Ioannidis   +2 more
doaj   +1 more source

Alter-Globalization as a Riot of the (Alter) Everyday-Man [PDF]

, 2011
This paper is a short review on the appearance and development of the Globalization and the more recent Alter-Globalization movement and the influence of the two on the life of the ordinary people, and questions the adequacy of "global-local" dichotomy ...
Trendafilov, Dimitar
core