Results 51 to 60 of about 636,756 (264)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Replication marketplaces would help science to become more self-correcting
Royal Society Open ScienceIndependent replications are very rare in the behavioural and social sciences. This is problematic because they can help to detect ‘false positives’ in published research and, in turn, contribute to scientific self-correction.
Joachim Hüffmeier, Clara Kühner
doaj +1 more source
Electrically programmable solid-state metasurfaces via flash localised heating
Light: Science & Applications, 2023 A rapid and programmable amplitude modulator based on the thermo-optical effect has been demonstrated by integrating transparent microheaters with metasurfaces.
Khosro Zangeneh Kamali +7 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Journal of Trial and ErrorIf a study is preregistered, but nobody checks it during review, does it mean anything? The purpose of this preregistered study was to better understand how editors and reviewers engage with preregistration plans during the review process.
Moin Syed
doaj +1 more source
Assessing replication success: a taxonomy and systematic comparison of replication success measures for prospective replications [PDF]
Royal Society Open ScienceReplication studies are recognized as essential to the scientific process. Numerous measures have been developed to quantify replication success. Most measures were developed for post hoc replications, in which the primary study has been conducted and ...
Dennis Kondzic +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
How the pandemic affected psychological research
Royal Society Open ScienceIn the wake of the COVID-19 pandemic, many journals swiftly changed their editorial policies and peer-review processes to accelerate the provision of knowledge about COVID-related issues to a wide audience.
Mario Gollwitzer +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source