Results 221 to 230 of about 3,214,671 (359)

The ATM Kinase Inhibitor AZD0156 is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and is an Attractive Candidate for Medicinal Chemistry Optimisation Ag…

Angewandte Chemie International Edition, Accepted Article.
New compounds targeting human malaria parasites are critical for effective malaria control and elimination. Here, we pursued the imidazoquinolinone AZD0156 (MMV1580483), a human ataxia‐telangiectasia mutated (ATM) kinase inhibitor that completed Phase I clinical trials as an anticancer agent.
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Gibhard, Dale Taylor, Meta Leshabane, Henrico Langeveld, Tayla Rabie, Janette Reader, Mariëtte van der Watt, Nelius Venter, Erica Erlank, Ayesha S. Aswat, Lizette L. Koekemoer, Tomas Yeo, Jin H. Jeon, David A. Fidock, Francisco Javier Gamo, Sergio Wittlin, Jacquin C. Niles, Manuel Llinas, Lauren B. Coulson, Lyn-Marié Birkholtz, Kelly Chibale   +33 more
wiley   +1 more source

Functional connectivity in behavioral variant frontotemporal dementia

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Decreased FC in the Salience Network (SN) is the most consistent finding in bvFTD. The brain's functional architecture is less interconnected and efficient in bvFTD. Symptom, behavior, cognition and disease severity are associated with changes in FC. Abstract Introduction Functional connectivity (FC)—which reflects relationships between neural activity
Luiz Kobuti Ferreira, Olof Lindberg, Alexander F Santillo, Lars‐Olof Wahlund   +3 more
wiley   +1 more source

Processing efficiency in pediatric cancer survivors: A review and operationalization for outcomes research and clinical utility

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Objective Childhood cancer and cancer‐related treatments disrupt brain development and maturation, placing survivors at risk for cognitive late effects. Given that assessment tools vary widely across researchers and clinicians, it has been daunting to identify distinct patterns in outcomes across diverse cancer types and to implement ...
Julie A. Trapani, Donna L. Murdaugh
wiley   +1 more source

Inequality in Utilization of Dental Services: A Systematic Review and Meta-analysis

American Journal of Public Health, 2018
S. F. Reda, Seif Reda, W. Thomson, F. Schwendicke   +3 more
semanticscholar   +1 more source

Outcomes of Acute Invasive Fungal Rhinosinusitis Patients Treated with Retrobulbar Amphotericin B Injections versus Orbital Exenteration

International Forum of Allergy &Rhinology, EarlyView.
Jakob L. Fischer, Nikitha Kosaraju, Katherine M. Lucarelli, Christine R. Wells, Connie M. Sears, Reem Karmouta, Ashley S. Shirriff, Maxwell Weng, Jeffrey D. Suh, Jivianne T. Lee, Daniel M. Beswick, Daniel B. Rootman, Marilene B. Wang   +12 more
wiley   +1 more source

closo‐Carboranyl Analogs of β‐Arylethylamines: Direct Synthesis from Alkenes via EnT‐Catalysis

Angewandte Chemie International Edition, Accepted Article.
closo‐Carboranes are icosahedral carbon‐boron clusters with unique properties and broad applicability. They particularly stand out in the context of drug development as privileged structural motifs for boron neutron capture therapy (BNCT) and as highly hydrophobic bioisosteres for the rotational volume of phenyl rings.
Fritz Paulus, Corinna Heusel, Marc Jaspers, Lilli M. Amrehn, Florian Schreiner, Debanjan Rana, Constantin G. Daniliuc, Michael Ryan Hansen, Frank Glorius   +8 more
wiley   +1 more source

Higher scores on autonomic symptom scales in pediatric patients with neurodevelopmental disorders of known genetic etiology

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Introduction Features of underlying autonomic dysfunction, including sleep disturbances, gastrointestinal problems, and atypical heart rate, have been reported in neurodevelopmental conditions, including autism spectrum disorder (ASD). The current cross‐sectional, between‐groups study aimed to quantify symptoms of autonomic dysfunction in a ...
Antoinette S DiCriscio, KE Wain, J Smith, D Beiler, LK Walsh, K Holdren, Vanessa Troiani   +6 more
wiley   +1 more source

Blue‐to‐Green Fine‐Tunable Narrowband Delayed Fluorescence in Peripherally Dendritic Modified Bis‐Indolocarbazoles

Angewandte Chemie International Edition, Accepted Article.
Highly efficient narrowband organic luminophores offer immense potentials for organic light‐emitting diodes (OLEDs) with high color purity of electroluminescence (EL). Appropriately controlling their structural relaxation and vibronic couplings between the excited and ground states enables the desired narrowband emissions.
Jun Hyeon Lee, Takumi Watanabe, Lars Hartmann, Takuma Yasuda   +3 more
wiley   +1 more source

4D Printing of Composite Thermoplastic Elastomers for Super‐Stretchable Soft Artificial Muscles

Journal of Applied Polymer Science, EarlyView.
ABSTRACT This study explores the development of soft, super‐stretchable artificial muscles by 4D printing of composite thermoplastic elastomers. A propylene‐based elastomer, combined with carbon black (CB) nanoparticles, is utilized to develop nanocomposite elastomers with enhanced mechanical properties.
Abbas Bayati, Davood Rahmatabadi, Mahdi Khajepour, Majid Baniassadi, Karen Abrinia, Mahdi Bodaghi, Mostafa Baghani   +6 more
wiley   +1 more source

Utilization of maternal healthcare services in low- and middle-income countries: a systematic review and meta-analysis. [PDF]

Syst Rev
Baten A, Biswas RK, Kendal E, Bhowmik J.
europepmc   +1 more source