Muscle Fatigue from the Perspective of a Single Crossbridge [PDF]
, 2016 The repeated intense stimulation of skeletal muscle rapidly decreases its force- and motion-generating capacity. This type of fatigue can be temporally correlated with the accumulation of metabolic by-products, including phosphate (Pi) and protons (H ...
Debold, Edward Patrick +3 more
core +1 more source
Acidosis Is a Key Regulator of Osteoblast Ecto-Nucleotidase Pyrophosphatase/Phosphodiesterase 1 (NPP1) Expression and Activity [PDF]
, 2015 Previous work has shown that acidosis prevents bone nodule formation by osteoblasts in vitro by inhibiting mineralisation of the collagenous matrix.
Arnett, T R +4 more
core +2 more sources
Advanced Science, EarlyView.Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen +7 more
wiley +1 more source
Severe traumatic brain injury in children – are the results improving?
Swiss Medical Weekly, 2002 Questions under study: Traumatic brain injury (TBI) remains an important cause of mortality and morbidity in children. Medical management is constantly being refined, and thus results should improve.
Jürg Pfenninger, Alessandro Santi
doaj +1 more source
NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis
Scientific Reports, 2018 Expression of the glutamine transporter SNAT3 increases in kidney during metabolic acidosis, suggesting a role during ammoniagenesis. Microarray analysis of Nrf2 knock-out (KO) mouse kidney identified Snat3 as the most significantly down-regulated ...
Adam Lister +15 more
semanticscholar +1 more source
Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases
Advanced Science, EarlyView.Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh +17 more
wiley +1 more source
Case Reports : Topiramate, a concealed cause of severe metabolic acidosis [PDF]
, 2017 Severe metabolic acidosis is common among critically ill patients, and topiramate is a rare cause that may fail recognition. We report a lady with acute encephalopathy who had severe non-anion gap metabolic acidosis that served as the clue leading to ...
Lovinger, Daniel +3 more
core +1 more source
Advanced Science, EarlyView.Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin +5 more
wiley +1 more source
Distal renal tubular acidosis a rarely diagnosed cause of failure to thrive: A report of three cases
Ibom Medical Journal, 2007 SUMMARY Three cases of distal renal tubular acidosis aged between 6 - 12weeks are described. The presenting features included lethargy, refusal to feed, marked periodic respiration, vomiting and recurrent episode of unexplained metabolic acidosis.
Adeleke SI, Asani MO
doaj +1 more source
Oh wait … It isn’t MUDPILES! Acute toxic encephalopathy with an interesting anion gap metabolic acidosis resulting in prolonged invasive mechanical ventilation [PDF]
, 2021 Khalid Sawalha +2 more
openalex +1 more source