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Phenformin-associated Metabolic Acidosis

Diabetes, 1976
We report 18 consecutive phenformin-treated diabetic patients admitted to this Medical Service acutely ill with metabolic acidosis. Lactic acidosis was anticipated, and documented, in all. Also, however, though most of the patients had only weakly positive, or even negative, serum reactions with the nitroprusside reagent, all were found to have ...
Milford Fülöp, M Fülöp
exaly   +3 more sources

Metabolic Acidosis

AACN Clinical Issues: Advanced Practice in Acute and Critical Care, 1997
Metabolic acidosis is a pathophysiologic state that is associated with serious morbidities and mortality. The diagnosis of metabolic acidosis is perplexing for novice and expert advanced practice nurses for many reasons. Its differential diagnosis is broad and includes common and rare, complex disease.
N, Szaflarski, C W, Hanson
openaire   +3 more sources

Metabolic Acidosis

Emergency Medicine Clinics of North America, 1989
This article reviews acid-base homeostasis and discusses the approach to the acidotic patient, with special reference to problems commonly encountered in emergency practice. General principles of therapy are presented, and their application to specific types of life-threatening metabolic acidosis addressed.
T, Kearns, A B, Wolfson
openaire   +2 more sources

Metabolic Acidosis in Sepsis

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2010
Metabolic acidosis is very common in critically ill septic patients. Acidosis may be a result of the underlying pathophysiology, but it also may be the result of the way in which those patients are managed. Chloride-associated acidosis is frequent and is potentially aggravated during fluid resuscitation. The severity of metabolic acidosis is associated
Alexandre Toledo, Maciel   +2 more
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Topiramate and Metabolic Acidosis

Epilepsia, 1999
Summary: Topiramate (TPM) is a novel antiepileptic medication (AED) with at least three mechanisms of action. A possible fourth mechanism, that of a carbonic anhydrase inhibitor, also may contribute to its antiepileptic properties. We report a patient with intractable epilepsy and normal renal function who developed a normal anion gap metabolic ...
A, Wilner, K, Raymond, R, Pollard
openaire   +2 more sources

Metabolic Acidosis

Advances in Kidney Disease and Health
Metabolic acidosis is a common disorder that occurs in a variety of clinical settings. The kidney maintains acid-base homeostasis through the elimination of protons and reabsorption/generation of bicarbonate. Metabolic acidosis develops when these mechanisms are overwhelmed or impaired, in situations such as rapid production of nonvolatile acids ...
Keiko I, Greenberg, Stewart H, Lecker
openaire   +3 more sources

Treatment of metabolic acidosis

Current Opinion in Critical Care, 2003
Metabolic acidosis is characterized by a decrease of the blood pH associated with a decrease in the bicarbonate concentration. This may be secondary to a decrease in the strong ion difference or to an increase in the weak acids concentration, mainly the inorganic phosphorus. From a conceptual point of view, two types of nontoxic metabolic acidosis must
Jacques, Levraut, Dominique, Grimaud
openaire   +2 more sources

Hyperchloraemic metabolic acidosis

Emergency Medicine Journal, 2008
Cholestyramine carries a risk of hyperchloraemic metabolic acidosis. Being cognisant of this drug-induced adverse event may reduce diagnostic delays. Emergency physicians should be alert about this condition, in particular among patients with pre-existing chronic kidney disease, or who are taking spironolactone.
F S Y, Fan   +3 more
openaire   +2 more sources

Metabolic Acidosis

Respiratory Care, 2001
Metabolic acidosis occurs in a number of diseases and even certain normal activities such as heavy exercise. It arises from increased endogenous acid production, exogenous acid (or acid-precursor) administration, base losses, and depression of renal acid secretion.
openaire   +2 more sources

PHENFORMIN AND METABOLIC ACIDOSIS

The Lancet, 1972
Abstract A patient with oliguric renal failure complicating accelerated hypertension was given phenformin and ethylœstrenol as fibrinolytic therapy. On the fifth day of this treatment a profound and fatal metabolic acidosis developed despite good control of uraemia by peritoneal dialysis. The acidosis was resistant to 2500 meq.
G A, MacGregor   +2 more
openaire   +2 more sources

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