Results 81 to 90 of about 22,882 (221)

Maximal exercise at high altitude does not exacerbate inflammation in the human brain

The Journal of Physiology, EarlyView.
Abstract figure legend This study investigated arterial–internal jugular venous (IJV) exchange of cytokines in response to low‐intensity and maximal cycling exercise at sea level and following 6–8 days at 3800 m a.s.l. There was a shift towards net release of interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), monocyte chemoattractant protein‐1 (MCP‐1) and ...
Hannah G. Caldwell, Travis D. Gibbons, Connor A. Howe, Jack S. Talbot, Elliott J. Jenkins, L. Madden Brewster, Justin A. Monteleone, Jay M. J. R. Carr, Andrew R. Steele, Michael Stembridge, David B. MacLeod, Philip N. Ainslie   +11 more
wiley   +1 more source

Severe metabolic alkalosis with fludrocortisone therapy—a case report

Emergency and Critical Care Medicine
. Background. We present an atypical case of severe metabolic alkalosis, not reported in the literature to date. Case Presentation. Owing to concerns of apneas and desaturation, a 75-year-old man presented to the emergency department with significantly ...
Grace Williams, Honor Hinxman
doaj   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Moderate hyperventilation during intravenous anesthesia increases net cerebral lactate efflux [PDF]

, 2014
BACKGROUND:: Hyperventilation is known to decrease cerebral blood flow (CBF) and to impair cerebral metabolism, but the threshold in patients undergoing intravenous anesthesia is unknown. The authors hypothesized that reduced CBF associated with moderate
Grüne, F. (Frank), Kazmaier, S. (Stephan), Sonntag, B. (Barbara), Stolker, R.J. (Robert), Weyland, A. (Andreas)   +4 more
core   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

Severe Hypertriglyceridemia Without Pancreatitis Causing Total Pseudohypocalcemia With True Ionized Symptomatic Hypocalcemia: A Diagnostic Pitfall

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Severe hypertriglyceridemia (HTG) can interfere with laboratory assays. HTG‐induced pancreatitis usually presents with hypocalcemia, but the effect of severe HTG, with no associated pancreatitis, on calcium levels is not well described. We present a 25‐year‐old male with severe HTG and diabetes who presented with generalized weakness, nausea ...
Mohamed Abuelazm, Marwah Algodi, Ahmed W. Hageen, Bassam Al Haly, Asawer Alsaeedi, Abdelrahman Awad, Hatem Eltaly, Omar Saab   +7 more
wiley   +1 more source

Pedigree and Functional Analysis of Two Cryptic OTC Variants Causing Ornithine Transcarbamylase Deficiency in Two Unrelated Chinese Male Patients

Molecular Genetics &Genomic Medicine, Volume 14, Issue 5, May 2026.
Two unrelated Chinese male OTCD‐suspected patients harbored an OTC synonymous variant (c.663G>A, p.Lys221Lys) and a novel de novo in‐frame variant (c.756_761dupAGCAGC, p.Ala253_Ala254dup); minigene analysis confirmed the synonymous variant induces exon 6 skipping with 41 amino acid deletion (c.541_663del, p.Glu181_Lys221del).
Qingming Wang, Huimin Xiao, Fang Zhang, Hui Li, Juan Zhao, Haiming Yuan   +5 more
wiley   +1 more source

Unexpected metabolic alkalosis in a newborn from denied pregnancy: case report

Egyptian Pediatric Association Gazette
Background Metabolic alkalosis is characterized by increased pH (> 7.45) and serum bicarbonate levels. In the early postnatal period, metabolic alkalosis is an uncommon problem, and its etiology is often due to maternal disorders. In the prenatal period,
Cusmano Carolina, Bianco Carlo, Cerasani Jacopo, Boschero Marta, Piceni Giorgia, Alberto Ricotti   +5 more
doaj   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source