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Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
Advanced Science, EarlyView.The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang +14 more
wiley +1 more source
Advanced Science, EarlyView.In vivo SALI therapy is achieved by scavenging intracellular ROS levels, downregulating inflammatory factors expression levels, inducing macrophage M2 directional polarization, and activating Keap1/Nrf‐2/HO‐1 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation, and promote liver tissue repair. Abstract Sepsis
Tao Qin +21 more
wiley +1 more source
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Measurements in Musculoskeletal Radiology, 2019
This chapter provides an overview of techniques to measure bone mass and structure as well as techniques to measure vertebral deformity. The current standard technique to measure bone mass is dual X-ray absorptiometry (DXA), which allows to classify bone mineral density as normal, osteopenic, and osteoporotic using so-called T-scores. It also allows to
T. Link
semanticscholar +3 more sources
This chapter provides an overview of techniques to measure bone mass and structure as well as techniques to measure vertebral deformity. The current standard technique to measure bone mass is dual X-ray absorptiometry (DXA), which allows to classify bone mineral density as normal, osteopenic, and osteoporotic using so-called T-scores. It also allows to
T. Link
semanticscholar +3 more sources
Current Diagnostic Pathology, 2002 The patient is an 80-yr-old woman who was referred because of findings on a head CT “suggestive of Paget’s disease.” She gave a history of generalized vague headache for 68 mo as well as decreased hearing in both ears for the last year. There were no complaints of dizziness or visual changes.
Michael Kleerekoper +3 more
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Archives of Disease in Childhood: Fetal and Neonatal Edition, 2019
Metabolic bone disease of prematurity (MBDP) is characterised by skeletal demineralisation, and in severe cases it can result in fragility fractures of long bones and ribs during routine handling. MBDP arises from prenatal and postnatal factors.
A. Chinoy, M. Z. Mughal, R. Padidela
semanticscholar +1 more source
Metabolic bone disease of prematurity (MBDP) is characterised by skeletal demineralisation, and in severe cases it can result in fragility fractures of long bones and ribs during routine handling. MBDP arises from prenatal and postnatal factors.
A. Chinoy, M. Z. Mughal, R. Padidela
semanticscholar +1 more source
Medical Journal of Australia, 1995
Metabolic bone diseases often present in old age and some are more easily treatable than others. Osteoporosis is best managed by prevention, with maximisation of peak bone density and reduction of subsequent bone loss. Although hormone replacement therapy is most useful in prevention, it also has a role in established osteoporosis.
T. J. Martin, V. Grill
openaire +3 more sources
Metabolic bone diseases often present in old age and some are more easily treatable than others. Osteoporosis is best managed by prevention, with maximisation of peak bone density and reduction of subsequent bone loss. Although hormone replacement therapy is most useful in prevention, it also has a role in established osteoporosis.
T. J. Martin, V. Grill
openaire +3 more sources
Imaging Findings of Metabolic Bone Disease.
Radiographics, 2016Metabolic bone diseases are a diverse group of diseases that result in abnormalities of (a) bone mass, (b) structure mineral homeostasis, (c) bone turnover, or (d) growth.
Connie Y. Chang +5 more
semanticscholar +1 more source