Results 31 to 40 of about 903,544 (342)

Secondary Osteoporosis and Metabolic Bone Diseases

Journal of Clinical Medicine, 2022
Fragility fracture is a worldwide problem and a main cause of disability and impaired quality of life. It is primarily caused by osteoporosis, characterized by impaired bone quantity and or quality.
M. Sobh, M. Abdalbary, Sherouk Elnagar, Eman Nagy, N. Elshabrawy, Mostafa Abdelsalam, K. Asadipooya, A. El-Husseini   +7 more
semanticscholar   +1 more source

Risk factors analysis and prevention of metabolic bone disease of prematurity

Medicine, 2018
The present study aims to analyze the risk factors for metabolic bone disease (MBD) of prematurity. A total of 238 preterm infants who were born at
Wenhao Chen, Changyi Yang, Han-qiang Chen, Baoquan Zhang   +3 more
semanticscholar   +1 more source

Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management

Genes, 2022
Hereditary metabolic bone diseases are characterized by genetic abnormalities in skeletal homeostasis and encompass one of the most diverse groups among rare diseases.
N. Charoenngam, Aryan Nasr, A. Shirvani, M. Holick   +3 more
semanticscholar   +1 more source

Establishing Reference Intervals for Bone Turnover Markers in the Healthy Shanghai Population and the Relationship with Bone Mineral Density in Postmenopausal Women

International Journal of Endocrinology, 2013
The reference ranges of bone turnover markers (BTMs) were important during the treatment of osteoporosis, and the associations with bone mineral density (BMD) were controversial.
Wei-Wei Hu, Zeng Zhang, Jin-Wei He, Wen-Zhen Fu, Chun Wang, Hao Zhang, Hua Yue, Jie-Mei Gu, Zhen-Lin Zhang   +8 more
doaj   +1 more source

Feasibility of quantitative ultrasonography for the detection of metabolic bone disease in preterm infants — systematic review

Pediatric Radiology, 2018
Metabolic bone disease of prematurity is characterised by disordered bone mineralisation and is therefore an increased fracture risk. Preterm infants are especially at risk due to incomplete in utero bone accretion during the last trimester.
Liting Tong, J. S. Gopal-Kothandapani, A. Offiah   +2 more
semanticscholar   +1 more source

Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis

Frontiers in Pharmacology, 2021
Nitazoxanide (NTZ) is an FDA-approved anti-parasitic drug with broad-spectrum anti-infective, anti-inflammatory, and antineoplastic potential. However, its regulatory effects on osteoclastogenesis and the underlying mechanisms remain unclear. The present
Chang-hong Li, Chang-hong Li, Zi-rui Lü, Zhen-da Zhao, Zhen-da Zhao, Xin-yu Wang, Hui-jie Leng, Hui-jie Leng, Yan Niu, Mo-pei Wang, Mo-pei Wang   +10 more
doaj   +1 more source

Metabolic Bone Diseases and New Drug Developments

Biomolecules & Therapeutics, 2022
Metabolic bone diseases are serious health issues worldwide, since several million individuals over the age of 50 are at risk of bone damage and should be worried about their bone health. One in every two women and one in every four men will break a bone
V. Natesan, Sung-jin Kim
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva

Orphanet Journal of Rare Diseases, 2020
Background Genetic contributors to cardiac arrhythmias are often found in cardiovascular conduction pathways and ion channel proteins. Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare disease of massive heterotopic ossification caused by a ...
Samuel Kou, Carmen De Cunto, Geneviève Baujat, Kelly L. Wentworth, Donna R. Grogan, Matthew A. Brown, Maja Di Rocco, Richard Keen, Mona Al Mukaddam, Kim-Hanh le Quan Sang, Umesh Masharani, Frederick S. Kaplan, Robert J. Pignolo, Edward C. Hsiao   +13 more
doaj   +1 more source