Results 181 to 190 of about 182,790 (263)

Oral glucose absorption is enhanced in early metabolic dysfunction-associated steatotic liver disease. [PDF]

Diabetologia
Tricò D, Wu T, Cimbalo N, Chiriacò M, Xie C, Sacchetta L, Nesti L, Gallo S, Santoni L, Masoni MC, Petralli G, Fiorentino TV, Bizzotto R, Scozzaro MT, Frascerra S, Baldi S, Brunetto MR, Mari A, Rayner CK, Natali A.   +19 more
europepmc   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

The glymphatic system clears amyloid beta and tau from brain to plasma in humans. [PDF]

Nat Commun
Dagum P, Elbert DL, Giovangrandi L, Singh T, Venkatesh VV, Corbellini A, Kaplan RM, Levendovszky SR, Ludington E, Yarasheski K, Lowenkron J, VandeWeerd C, Lim MM, Iliff JJ.   +13 more
europepmc   +1 more source

Engineered AuNPs/fMWCNT Nanocomposite Electrodes for High‐Sensitivity Methylglyoxal Sensing in Saliva and Sweat for Non‐Invasive Diabetes Monitoring

Advanced Healthcare Materials, EarlyView.
An AuNPs/fMWCNT nanocomposite‐modified screen‐printed carbon electrode was engineered via sequential electrodeposition and integrated into a 3D‐printed microfluidic platform for ultrasensitive methylglyoxal detection. The non‐invasive sensing platform enables rapid analysis in saliva and sweat, highlighting strong potential for wearable point‐of‐care ...
Ahadul Amin Soshi, Md Younus Ali, Dadbeh Pazuki, Matiar M.R. Howlader   +3 more
wiley   +1 more source

Resting and Exercise Lactate Dynamics in Heart Failure: Guiding Therapeutic Optimization. [PDF]

Biomedicines
Ferro A, Segreti A, Tetaj N, Ciancio M, Crispino SP, Cricco R, Fossati C, Pigozzi F, Grigioni F.   +8 more
europepmc   +1 more source

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

Advanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky, Elvis Pandzic, Sean Porazinski, J Justin Gooding, Kristopher A Kilian   +4 more
wiley   +1 more source

Microglial metabolic reprogramming drives the therapeutic effects of bavachinin on brain network function and memory in Alzheimer's disease. [PDF]

Front Pharmacol
Zou Y, Lin Y, Zhang C, Li Y, Chen X, Ma X, Chen K, Liang B, Liang P.   +8 more
europepmc   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

Physiologically Based Pharmacokinetic-Pharmacodynamic-Based Quantification of Exposure-Response for Sodium Tanshinone IIA Sulfonate in Normal and Cerebral Ischemia-Reperfusion Injury Rats. [PDF]

Biology (Basel)
Chen Y, Zhang J, Zhang Y, Qin T, Jin W, Wang Y, Chen Y, Yu L, Zhang L.   +8 more
europepmc   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source