Results 91 to 100 of about 1,855,857 (359)

Changes in frailty, intensive blood pressure treatment, and risks of adverse clinical outcomes: a post hoc analysis of the SPRINT trial

BMC Medicine
Background Frailty is becoming a common health issue and its status changes overtime. However, the impact of the frailty status changes on clinical outcomes is unknown.
Xiaoyun Zhang, Xi Meng, Siyu Wang, Qing Lin, Yueyue Wang, Yu Xiang, Kan Wang, Xuan Zhao, Mian Li, Tiange Wang, Zhiyun Zhao, Jieli Lu, Min Xu, Jie Zheng, Yufang Bi, Yu Xu   +15 more
doaj   +1 more source

非酒精性脂肪性肝病与血糖的缓解和进展

Journal of Diabetes, 2022
Background The study aimed to explore the associations of nonalcoholic fatty liver disease (NAFLD) with the remission and progression along the glycemic continuum.
Zhuojun Xin, Jiaojiao Huang, Qiuyu Cao, Jialu Wang, Ruixin He, Tianzhichao Hou, Yi Ding, Jieli Lu, Min Xu, Tiange Wang, Zhiyun Zhao, Weiqing Wang, Guang Ning, Yufang Bi, Yu Xu, Mian Li   +15 more
doaj   +1 more source

Structural and metabolic brain correlates of arithmetic word‐problem solving in Huntington's disease [PDF]

, 2023
Andrea Horta‐Barba, Saül Martínez‐Horta, Frederic Sampedro, Jesús Pérez‐Pérez, Valle Camacho, Javier Pagonabarraga, Jaime Kulisevsky   +6 more
openalex   +1 more source

Promoting metabolic inefficiency for metabolic disease

iScience, 2023
Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss.
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]

, 2013
Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A, Doyle, Jason, Fedorak, Richard N, Foshaug, Rae R, Slupsky, Carolyn M, Sydora, Beate C, Tso, Victor K   +6 more
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Use of hypoglycemic plants by Tunisian diabetic patients

Alexandria Journal of Medicine, 2013
Introduction: The recourse to the herbal medicines in treating diabetes is frequent in Africa and especially in Tunisia. Its practice is transmitted orally and ritually from generation to generation.
Rym Ben Othman, Hazar Ibrahim, Amina Mankai, Nawress Abid, Nedia Othmani, Nedia Jenhani, Hajer Tertek, Nebil Trabelsi, Abdelmajid Trimesh, Faika Ben Mami   +9 more
doaj   +1 more source

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases [PDF]

, 2016
Oxidative stress is generally considered as the consequence of an imbalance between pro- and antioxidants species, which often results into indiscriminate and global damage at the organismal level.
Conti, V, Corbi, G, De Lise, F, Di Donato, A, Filippelli, A, Izzo, V, Manzo, V, Russomanno, G   +7 more
core   +2 more sources

Metabolic storage diseases: amyloidosis

Clinics in Liver Disease, 2004
This article provides an overview of the current concepts in pathogenesis, epidemiology, clinical significance, and treatment options for amyloidosis. Emphasis is given to hepatic amyloidosis, which ranges from a clinically insignificant histologic curiosity to a harbinger of widespread disease accompanied by a poor prognosis.
Brunt, E.M., Tiniakos, D.G.
openaire   +3 more sources