Results 11 to 20 of about 284,867 (287)

Flux-P: Automating Metabolic Flux Analysis [PDF]

Metabolites, 2012
Quantitative knowledge of intracellular fluxes in metabolic networks is invaluable for inferring metabolic system behavior and the design principles of biological systems.
Birgitta E. Ebert, Anna-Lena Lamprecht, Bernhard Steffen, Lars M. Blank   +3 more
doaj   +5 more sources

p13CMFA: Parsimonious 13C metabolic flux analysis.

PLoS Computational Biology, 2019
Deciphering the mechanisms of regulation of metabolic networks subjected to perturbations, including disease states and drug-induced stress, relies on tracing metabolic fluxes.
Carles Foguet, Anusha Jayaraman, Silvia Marin, Vitaly A Selivanov, Pablo Moreno, Ramon Messeguer, Pedro de Atauri, Marta Cascante   +7 more
doaj   +5 more sources

Metabolic flux analysis of secondary metabolism in plants

Metabolic Engineering Communications, 2020
Numerous secondary metabolites from plants are important for their medicinal, nutraceutical or sensory properties. Recently, significant progress has been made in the identification of the genes and enzymes of plant secondary metabolic pathways.
Meng-Ling Shih, John A. Morgan
doaj   +3 more sources

Principal metabolic flux mode analysis [PDF]

Bioinformatics, 2017
Abstract Motivation In the analysis of metabolism, two distinct and complementary approaches are frequently used: Principal component analysis (PCA) and stoichiometric flux analysis. PCA is able to capture the main modes of variability in a set of experiments and does not make many prior ...
Bhadra, Sahely, Blomberg, Peter, Castillo, Sandra, Rousu, Juho   +4 more
openaire   +4 more sources

Interpreting metabolic complexity via isotope-assisted metabolic flux analysis. [PDF]

Trends Biochem Sci, 2023
Isotope-assisted metabolic flux analysis (iMFA) is a powerful method to mathematically determine the metabolic fluxome from experimental isotope labeling data and a metabolic network model. While iMFA was originally developed for industrial biotechnological applications, it is increasingly used to analyze eukaryotic cell metabolism in physiological and
Moiz B, Sriram G, Clyne AM.
europepmc   +3 more sources

Thermodynamics-Based Metabolic Flux Analysis [PDF]

Biophysical Journal, 2007
A new form of metabolic flux analysis (MFA) called thermodynamics-based metabolic flux analysis (TMFA) is introduced with the capability of generating thermodynamically feasible flux and metabolite activity profiles on a genome scale. TMFA involves the use of a set of linear thermodynamic constraints in addition to the mass balance constraints ...
Henry, Christopher S., Broadbelt, Linda J., Hatzimanikatis, Vassily   +2 more
openaire   +2 more sources

mfapy: An open-source Python package for 13C-based metabolic flux analysis

Metabolic Engineering Communications, 2021
13C-based metabolic flux analysis (13C-MFA) is an essential tool for estimating intracellular metabolic flux levels in metabolic engineering and biology.
Fumio Matsuda, Kousuke Maeda, Takeo Taniguchi, Yuya Kondo, Futa Yatabe, Nobuyuki Okahashi, Hiroshi Shimizu   +6 more
doaj   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +16 more sources

Stoichiometry Based Steady-State Hepatic Flux Analysis: Computational and Experimental Aspects

Metabolites, 2012
The liver has many complex physiological functions, including lipid, protein and carbohydrate metabolism, as well as bile and urea production. It detoxifies toxic substances and medicinal products. It also plays a key role in the onset and maintenance of
Mehmet A. Orman, John Mattick, Ioannis P. Androulakis, Francois Berthiaume, Marianthi G. Ierapetritou   +4 more
doaj   +1 more source