Results 21 to 30 of about 284,867 (287)
Quantifying Dynamic Regulation in Metabolic Pathways with Nonparametric Flux Inference [PDF]
, 2019 One of the central tasks in systems biology is to understand how cells regulate their metabolism. Hierarchical regulation analysis is a powerful tool to study this regulation at the metabolic, gene-expression, and signaling levels.
He, Fei, Stumpf, Michael P H
core +1 more source
Conservation of high-flux backbone in alternate optimal and near-optimal flux distributions of metabolic networks [PDF]
, 2008 Constraint-based flux balance analysis (FBA) has proven successful in predicting the flux distribution of metabolic networks in diverse environmental conditions. FBA finds one of the alternate optimal solutions that maximizes the biomass production rate.
Samal, Areejit
core +3 more sources
Bayesian metabolic flux analysis reveals intracellular flux couplings [PDF]
Bioinformatics, 2019 Abstract Motivation Metabolic flux balance analysis (FBA) is a standard tool in analyzing metabolic reaction rates compatible with measurements, steady-state and the metabolic reaction network stoichiometry.
Osmala, Maria +7 more
openaire +5 more sources
Model validation and selection in metabolic flux analysis and flux balance analysis. [PDF]
Biotechnol Prog, 2023 Abstract 13C‐Metabolic Flux Analysis (13C‐MFA) and Flux Balance Analysis (FBA) are widely used to investigate the operation of biochemical networks in both biological and biotechnological research. Both methods use metabolic reaction network models of metabolism operating at steady state so that reaction rates ...
Kaste JAM, Shachar-Hill Y.
europepmc +5 more sources
Frontiers in Microbiology, 2013 Synthetic biology enables metabolic engineering of industrial microbes to synthesize value-added molecules. In this, a major challenge is the efficient redirection of carbon to the desired metabolic pathways.
Ashish eMisra +6 more
doaj +1 more source
Flux networks in metabolic graphs [PDF]
, 2009 A metabolic model can be represented as bipartite graph comprising linked reaction and metabolite nodes. Here it is shown how a network of conserved fluxes can be assigned to the edges of such a graph by combining the reaction fluxes with a conserved ...
Dantzig G B +9 more
core +1 more source
Frontiers in Bioengineering and Biotechnology, 2016 Efficient redirection of microbial metabolism into the abundant production of desired bioproducts remains non-trivial. Here we used flux-based modeling approaches to improve yields of fatty acids in S. cerevisiae.
Amit Ghosh +9 more
doaj +1 more source
Analysis of metabolic flux using dynamic labeling and metabolic modeling [PDF]
, 2013 Metabolic fluxes and the capacity to modulate them are a crucial component of the ability of the plant cell to react to environmental perturbations. Our ability to quantify them and to attain information concerning the regulatory mechanisms which control
Fernie, A., Morgan, J.
core +2 more sources
Visual FTBL Generator: Visual Generation Tool for 13C-FLUX File [PDF]
Brazilian Archives of Biology and Technology, 2019 13C metabolic flux analysis (13C-MFA) has achieved increasing significance in quantitative metabolic system analysis in recent years. In 13C metabolic flux analysis, 13C-FLUX software is a major analytical tool.
Guojun Yu +3 more
doaj +1 more source
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]
, 2017 Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash +5 more
core +1 more source