Results 41 to 50 of about 284,867 (287)

Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics. [PDF]

, 2017
Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn To access publisher's full text version of this article.
Bordbar, Aarash, Paglia, Giuseppe, Palsson, Bernhard O, Rolfsson, Ottar, Sigurjónsson, Ólafur E, Yurkovich, James T   +5 more
core   +3 more sources

Decoding the coupled decision-making of the epithelial-mesenchymal transition and metabolic reprogramming in cancer

iScience, 2023
Summary: Cancer metastasis relies on an orchestration of traits driven by different interacting functional modules, including metabolism and epithelial-mesenchymal transition (EMT). During metastasis, cancer cells can acquire a hybrid metabolic phenotype
Madeline Galbraith, Herbert Levine, José N. Onuchic, Dongya Jia   +3 more
doaj   +1 more source

Double and multiple knockout simulations for genome-scale metabolic network reconstructions [PDF]

, 2015
Constraint-based modeling of genome-scale metabolic network reconstructions has become a widely used approach in computational biology. Flux coupling analysis is a constraint-based method that analyses the impact of single reaction knockouts on other ...
Bockmayr, Alexander, Goldstein, Yaron A. B.   +1 more
core   +2 more sources

From elementary flux modes to elementary flux vectors: Metabolic pathway analysis with arbitrary linear flux constraints.

PLoS Computational Biology, 2017
Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic pathways and have become an established tool for constraint-based modeling and metabolic network analysis.
Steffen Klamt, Georg Regensburger, Matthias P Gerstl, Christian Jungreuthmayer, Stefan Schuster, Radhakrishnan Mahadevan, Jürgen Zanghellini, Stefan Müller   +7 more
doaj   +1 more source

Using bioconductor package BiGGR for metabolic flux estimation based on gene expression changes in brain.

PLoS ONE, 2015
Predicting the distribution of metabolic fluxes in biochemical networks is of major interest in systems biology. Several databases provide metabolic reconstructions for different organisms.
Anand K Gavai, Farahaniza Supandi, Hannes Hettling, Paul Murrell, Jack A M Leunissen, Johannes H G M van Beek   +5 more
doaj   +1 more source

ΔFBA-Predicting metabolic flux alterations using genome-scale metabolic models and differential transcriptomic data.

PLoS Computational Biology, 2021
Genome-scale metabolic models (GEMs) provide a powerful framework for simulating the entire set of biochemical reactions in a cell using a constraint-based modeling strategy called flux balance analysis (FBA). FBA relies on an assumed metabolic objective
Sudharshan Ravi, Rudiyanto Gunawan
doaj   +1 more source

Quantitative Metabolomics and Instationary 13C-Metabolic Flux Analysis Reveals Impact of Recombinant Protein Production on Trehalose and Energy Metabolism in Pichia pastoris [PDF]

, 2014
Pichia pastoris has been recognized as an effective host for recombinant protein production. In this work, we combine metabolomics and instationary 13C metabolic flux analysis (INST 13C-MFA) using GC-MS and LC-MS/MS to evaluate the potential impact of ...
Albiol i Sala, Joan, Aljoscha Wahl, Carnicer Heras, Marc, Cueto Rojas, Hugo, Ferrer, Pau, Jordà Murria, Joel   +5 more
core   +2 more sources

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

ReMatch: a web-based tool to construct, store and share stoichiometric metabolic models with carbon maps for metabolic flux analysis

Journal of Integrative Bioinformatics, 2008
y ReMatch is a web-based, user-friendly tool that constructs stoichiometric network models for metabolic flux analysis, integrating user-developed models into a database collected from several comprehensive metabolic data resources, including KEGG ...
Pitkänen Esa, Åkerlund Arto, Rantanen Ari, Jouhten Paula, Ukkonen Esko   +4 more
doaj   +1 more source

Flux-based classification of reactions reveals a functional bow-tie organization of complex metabolic networks

, 2012
Unraveling the structure of complex biological networks and relating it to their functional role is an important task in systems biology. Here we attempt to characterize the functional organization of the large-scale metabolic networks of three ...
Giri, Varun, Jain, Sanjay, Krishna, Sandeep, Raghuram, Nandula, Samal, Areejit, Singh, Shalini   +5 more
core   +3 more sources