Results 71 to 80 of about 284,867 (287)

Characterizing cancer metabolism from bulk and single-cell RNA-seq data using METAFlux

Nature Communications, 2023
Cells often alter metabolic strategies under nutrient-deprived conditions to support their survival and growth. Characterizing metabolic reprogramming in the tumor microenvironment (TME) is of emerging importance in cancer research and patient care ...
Yuefan Huang, Vakul Mohanty, Merve Dede, Kyle Tsai, May Daher, Li Li, Katayoun Rezvani, Ken Chen   +7 more
doaj   +1 more source

Metabolite biomarker discovery for metabolic diseases by flux analysis [PDF]

, 2012
Metabolites can serve as biomarkers and their identification has significant importance in the study of biochemical reaction and signalling networks.
Ching, WK, Jiang, H, Li, L, Vassiliadis, VS   +3 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Characterizing steady states of genome-scale metabolic networks in continuous cell cultures

, 2017
We present a model for continuous cell culture coupling intra-cellular metabolism to extracellular variables describing the state of the bioreactor, taking into account the growth capacity of the cell and the impact of toxic byproduct accumulation.
Fernandez-de-Cossio-Diaz, Jorge, León, Kalet, Mulet, Roberto   +2 more
core   +6 more sources

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle [PDF]

, 2015
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production.
CAPUANI, FABRIZIO, DE MARTINO, ANDREA, DE MARTINO, DANIELE, MARINARI, Vincenzo   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Global organization of metabolic fluxes in the bacterium, Escherichia coli

, 2004
Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalyzed biochemical reactions, is the most investigated complex intercellular web of molecular interactions.
A Goldbeter, A Wagner, A-L Barabási, A.-L. Barabási, B. Kovács, D Segre, DM Wolf, E Fischer, E Ravasz, E. Almaas, F Canonaco, FR Blattner, H Jeong, HW Ma, J Stelling, JS Edwards, JS Edwards, JS Edwards, KI Goh, L Lovász, LH Hartwell, M Barthelemy, M Emmerling, MA Savageau, P Holme, R Heinrich, RL Smith, RU Ibarra, S Schuster, SY Gerdes, T Dandekar, T. Vicsek, U Sauer, Z. N. Oltvai   +33 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Flux-balance modelling of plant metabolism

Frontiers in Plant Science, 2011
Flux-balance modelling of plant metabolic networks provides an important complement to 13C-based metabolic flux analysis. Flux-balance modelling is a constraints-based approach in which steady-state fluxes in a metabolic network are predicted by using ...
Lee James Sweetlove, R. George eRatcliffe   +1 more
doaj   +1 more source

Augmenting Biogas Process Modeling by Resolving Intracellular Metabolic Activity [PDF]

, 2019
The process of anaerobic digestion in which waste biomass is transformed to methane by complex microbial communities has been modeled for more than 16 years by parametric gray box approaches that simplify process biology and do not resolve intracellular ...
Denny Popp, Dirk Benndorf, Dirk Benndorf, Fabian Bonk, Florian Centler, Sabine Koch, Steffen Klamt, Sören Weinrich   +7 more
core   +1 more source