Results 151 to 160 of about 1,023,457 (221)
Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities
The Journal of Physiology, EarlyView.Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley +1 more source
Kinematic‐calcium loops unravel impaired excitation–contraction coupling in MELAS‐affected cardioids
The Journal of Physiology, EarlyView.Abstract figure legend Representation of kinematic and calcium transient loop with respect to traditional time coplotting. Abstract Impaired Ca2+ handling, and in particular leakage from the sarcoplasmic reticulum, is a critical mechanism in metabolic diseases affecting the heart.
Margherita Burattini +7 more
wiley +1 more source
Myopathy following postoperative ablative radioiodine for follicular carcinoma of the thyroid
, 2009 Hermione C Price, Vijay JayagopalCentre for Diabetes and Endocrinology, York Hospital, York, UKAbstract: We highlight a case of disabling myopathy following radioablative iodine treatment for follicular carcinoma of the thyroid.
Vijay Jayagopal, Hermione C Price
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The Journal of Physiology, EarlyView.Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel +10 more
wiley +1 more source
Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability
The Journal of Physiology, EarlyView.Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi +12 more
wiley +1 more source
Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates
Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 10931-10949, December 2026.ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou +5 more
wiley +1 more source
Nursing &Health Sciences, Volume 28, Issue 4, December 2026.ABSTRACT This study aimed to analyze the associations among functional capacity, self‐care, and health‐related quality of life in patients with heart failure (HF). A cross‐sectional correlational study was conducted. Functional capacity was measured with the Duke Activity Status Index, self‐care with the European Heart Failure Self‐Care Behaviour Scale,
José Arthur Guimarães dos Santos +5 more
wiley +1 more source
Mitochondrial Bioenergetics in the Metabolic Myopathy Accompanying Peripheral Artery Disease. [PDF]
Front Physiol, 2017 Rontoyanni VG +5 more
europepmc +1 more source
A Case of Multiple Mitochondrial Dysfunctions Syndrome 1 and Review of the Literature
American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2409-2419, November 2026.ABSTRACT Multiple mitochondrial dysfunctions syndrome 1 (MMDS1, MIM #605711) due to NFU1 gene defects is an ultra‐rare autosomal recessive inborn error of metabolism associated with reduced function of NFU1 iron–sulfur cluster (ISC) scaffold protein.
Charles R. DiFalco +6 more
wiley +1 more source