Results 291 to 300 of about 898,161 (347)

Metabolic Networking

Science, 2012
A key design principle of bacterial metabolic networks is optimal performance, but not at the expense of adaptability.
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Metabolic Networks

2009
World Scientific Lecture Notes in Complex ...
Maria Concetta Palumbo, Lorenzo Farina, Alfredo Colosimo, Alessandro Giuliani   +3 more
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Genome‐scale metabolic networks

WIREs Systems Biology and Medicine, 2009
AbstractDuring the last decade, models have been developed to characterize cellular metabolism at the level of an entire metabolic network. The main concept that underlies whole‐network metabolic modeling is the identification and mathematical definition of constraints.
Marco, Terzer, Nathaniel D, Maynard, Markus W, Covert, Jörg, Stelling   +3 more
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Metabolic network sensitivity analysis

Journal of Theoretical Biology, 1982
Abstract A linear sensitivity analysis of metabolic regulation in nonsteady states is described. This treatment considers the effects of enzymatic and nonenzymatic reactions and spontaneous rapid equilibria. Sensitivity coefficients summarizing the influence of metabolite concentrations on reaction rates and pathway net flux are defined, as are ...
M C, Kohn, E, Chiang
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Metabolic Networks: Weighted Gene Correlation Network Analysis

2023
Weighted Gene Correlation Network Analysis (WGCNA) is used to build weighted gene networks representing direct interconnections among genes. This method is useful to identify gene modules associated with biological functions, revealing core functional differences between samples.
Desquilles, Lise, Musso, Orlando
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Profiling metabolic networks to study cancer metabolism

Current Opinion in Biotechnology, 2013
Cancer is a disease of unregulated cell growth and survival, and tumors reprogram biochemical pathways to aid these processes. New capabilities in the computational and bioanalytical characterization of metabolism have now emerged, facilitating the identification of unique metabolic dependencies that arise in specific cancers.
Karsten, Hiller, Christian M, Metallo
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Genome-Scale Metabolic Networks

2019
This chapter discusses the benefits of interpreting metabolomics data in the context of genome-scale metabolic networks. These networks gather all the metabolic reactions occuring in an organism, a tissue or a cell, thus providing a biological background to decipher the role of metabolites of interest.
Frainay, Clément, Jourdan, Fabien
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VRML metabolic network visualizer

Computers in Biology and Medicine, 2003
A successful date collection visualization should satisfy a set of many requirements: unification of diverse data formats, support for serendipity research, support of hierarchical structures, algorithmizability, vast information density, Internet-readiness, and other.
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Scale-Rich Metabolic Networks

Physical Review Letters, 2005
Recent research in biology has clarified many features of the global organization of metabolic networks, including the biochemical mechanisms responsible for power laws in metabolite degrees. The primary aim of this Letter is to give the simplest possible biochemical explanations and minimal toy models based on a highly optimized tolerance perspective,
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Modelling Metabolic Networks—The Theories of Metabolism

2013
Abstract There are several theoretical approaches to metabolism. Some of them give a greater place to the structure of the metabolic network symbolized by its stoichiometry matrix. The constraints in a metabolic network are very strong so that a lot of information can be derived from the stoichiometry matrix without any knowledge of the kinetic ...
Mazat, Jean-Pierre, Beauvoit, Bertrand
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