Results 71 to 80 of about 911,565 (297)

Hypergraph models of metabolism [PDF]

, 2014
In this paper, we employ a directed hypergraph model to investigate the extent to which environmental variability influences the set of available biochemical reactions within a living cell.
Chuzhanova, N, Crofts, JJ, Pearcy, N
core  

Signatures of currency vertices

, 2008
Many real-world networks have broad degree distributions. For some systems, this means that the functional significance of the vertices is also broadly distributed, in other cases the vertices are equally significant, but in different ways.
Albert R., Arita M., Buckley F., Caldarelli G., Ebel H., Gleiser P., Guimerà R., Guimerà R., Guimerà R., Holme P., Holme P., Holme P., Huss M., Lusseau D., Ma H.-W., Maslov S., Newman M. E. J., Newman M. E. J., Newman M. E. J., Newman M. E. J., Rosvall M., Solé R. V., Wagner A., Wasserman S., White J. G., Zhao J., Zhao J.   +26 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Temporal Dynamics of the Soil Metabolome and Microbiome During Simulated Anaerobic Soil Disinfestation

Frontiers in Microbiology, 2019
Significant interest exists in engineering the soil microbiome to attain suppression of soil-borne plant diseases. Anaerobic soil disinfestation (ASD) has potential as a biologically regulated disease control method; however, the role of specific ...
Shashika S. Hewavitharana, Emmi Klarer, Andrew J. Reed, Rachel Leisso, Brenton Poirier, Loren Honaas, David R. Rudell, Mark Mazzola   +7 more
doaj   +1 more source

Multinuclear NMR spectroscopy and isotopomer distribution analysis applied to metabolic phenotype characterization of complex systems [PDF]

, 2014
In the present work, the complex metabolic effects of a rag8 genetic mutation performed on Kluyveromyces lactis yeast cells is investigated with a specific, ‘information-rich’ analytical approach: differential NMR metabolomics. The use of such NMR-based
GORIETTI, DANIELA
core  

Learning Optimal Deep Projection of $^{18}$F-FDG PET Imaging for Early Differential Diagnosis of Parkinsonian Syndromes

, 2018
Several diseases of parkinsonian syndromes present similar symptoms at early stage and no objective widely used diagnostic methods have been approved until now.
AJ Hughes, CC Tang, D Eidelberg, D Zhang, F Gao, G Litjens, HI Suk, J Jiao, L Bi, L Zhou, R Li, S Fahn, S Lu, U Bagci, VK Ithapu, Y LeCun, Z Xu   +16 more
core   +1 more source

Metabolic network reductions [PDF]

, 2018
AbstractGenome-scale metabolic networks are exceptionally huge and even efficient algorithms can take a while to run because of the sheer size of the problem instances. To address this problem, metabolic network reductions can substantially reduce the overwhelming size of the problem instances at hand.
Tefagh, Mojtaba, Boyd, Stephen P.
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Diet shifts provoke complex and variable changes in the metabolic networks of the ruminal microbiome

Microbiome, 2017
Background Grazing mammals rely on their ruminal microbial symbionts to convert plant structural biomass into metabolites they can assimilate. To explore how this complex metabolic system adapts to the host animal’s diet, we inferred a microbiome-level ...
Sara M. Wolff, Melinda J. Ellison, Yue Hao, Rebecca R. Cockrum, Kathy J. Austin, Michael Baraboo, Katherine Burch, Hyuk Jin Lee, Taylor Maurer, Rocky Patil, Andrea Ravelo, Tasia M. Taxis, Huan Truong, William R. Lamberson, Kristi M. Cammack, Gavin C. Conant   +15 more
doaj   +1 more source