Results 131 to 140 of about 345,747 (340)

A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability

Molecular Systems Biology, 2009
During evolution, enzyme‐coding genes are acquired and/or replaced through lateral gene transfer and compiled into metabolic pathways. Gene regulatory networks evolve to fine tune biochemical fluxes through such metabolic pathways, enabling organisms to ...
Amy K Schmid, David J Reiss, Min Pan, Tie Koide, Nitin S Baliga   +4 more
doaj   +1 more source

Metabolic Reprogramming in Thyroid Cancer [PDF]

Endocrinology and Metabolism
Thyroid cancer is a common endocrine malignancy with increasing incidence globally. Although most cases can be treated effectively, some cases are more aggressive and have a higher risk of mortality.
Sang-Hyeon Ju, Minchul Song, Joung Youl Lim, Yea Eun Kang, Hyon-Seung Yi, Minho Shong   +5 more
doaj   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Dispensability of Escherichia coli's latent pathways

, 2011
Gene-knockout experiments on single-cell organisms have established that expression of a substantial fraction of genes is not needed for optimal growth.
A. E. Motter, Baba, Barab  si, Becker, Blank, Braunstein, Covert, Deluna, Deutscher, Edwards, Emmerling, Feist, Feist, Ferguson, Flores, Fong, Fong, Freilich, Gerdes, Giaever, Goyal, Gu, Hasona, Herring, Hillenmeyer, Hopkins, Hua, Ibarra, Ito, J. S. Lee, Kaufman, Klipp, Kupiec, Mahadevan, Motter, Motter, Nishikawa, Papp, Reed, Reed, S. P. Cornelius, Shi, Smith, Stern, Vinopal, Wagner   +45 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Single-cell transcriptomic analysis reveals metabolic and cellular heterogeneity in papillary thyroid carcinoma

Heliyon
Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Here, we investigated the cellular and metabolic heterogeneity of PTC using single-cell RNA sequencing.
Tian Wang, Chang-ding He, Jian Zhou, Lei Tao   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Modular decomposition of metabolic reaction networks based on flux analysis and pathway projection [PDF]

, 2007
Jeongah Yoon, Yaguang Si, Ryan P. Nolan, Kyongbum Lee   +3 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks [PDF]

, 2009
Xia Yang, Joshua L. Deignan, Hongxiu Qi, Jun Zhu, Su Qian, Judy Zhong, Gevork Torosyan, Sana Majid, Brie Falkard, Robert Kleinhanz, Jenny Karlsson, Lawrence W. Castellani, Sheena Mumick, Kai Wang, Tao Xie, Michael Coon, Chunsheng Zhang, Daria Estrada‐Smith, Charles R. Farber, Susanna S. Wang, Atila van Nas, Anatole Ghazalpour, Bin Zhang, Douglas J. MacNeil, John R. Lamb, Katrina M. Dipple, Marc L. Reitman, Margarete Mehrabian, Pek Yee Lum, Eric E. Schadt, Aldons J. Lusis, Thomas A. Drake   +31 more
openalex   +1 more source