Results 131 to 140 of about 363,947 (345)

POS1408 INTEGRATED METABOLOMICS AND PROTEOMICS NETWORK ANALYSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS HIGHLIGHTS METABOLIC AND IMMUNITY PATHWAYS ASSOCIATED WITH DISTINCTIVE CLINICAL PROFILES [PDF]

, 2023
Tomás Cerdó, C. Perez-Sanchez, M. Á. Aguirre, P. Seguí Azpilcueta, I. Sanchez-Pareja, L. Muñoz-Barrera, Christian A. Merlo, P. Ortiz Buitrago, D. Ruiz, M. C. Ábalos‐Aguilera, F. U. Pilar, N. Barbarroja Puerto, Eduardo Collantes‐Estévez, R. Ortega Castro, C. Lopez-Pedrera   +14 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability

Molecular Systems Biology, 2009
During evolution, enzyme‐coding genes are acquired and/or replaced through lateral gene transfer and compiled into metabolic pathways. Gene regulatory networks evolve to fine tune biochemical fluxes through such metabolic pathways, enabling organisms to ...
Amy K Schmid, David J Reiss, Min Pan, Tie Koide, Nitin S Baliga   +4 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

MULTI-OMICS INVESTIGATION OF METABOLIC FLUX NETWORKS IN CORE AND PERIPHERAL PATHWAYS

, 2021
160 pages ; Glycolytic metabolism of carbohydrates is extensively studied in bacteria, but gluconeogenic carbon sources (e.g., organic acids, aromatic compounds) that feed into the tricarboxylic acid cycle (TCA) are common substrates in environmental matrices and industrial feedstocks.
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Lactate Metabolism in Intervertebral Disc Degeneration: Unveiling Novel Mechanisms Through Bioinformatics

JOR Spine
Background Intervertebral disc degeneration (IDD) is a widespread issue associated with chronic lumbar pain and disability. This study aimed to identify lactate metabolism‐related genes in IDD and elucidate their mechanistic roles in disease progression.
Haiyan Sun, Mingwei He, Jinlei Pang, Xiangfei Guo, Yansong Huo, Jun Ma   +5 more
doaj   +1 more source

R spider: a network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases [PDF]

, 2010
Alexey V. Antonov, Esther Schmidt, Sabine Dietmann, Maria Krestyaninova, Henning Hermjakob   +4 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Single-cell transcriptomic analysis reveals metabolic and cellular heterogeneity in papillary thyroid carcinoma

Heliyon
Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Here, we investigated the cellular and metabolic heterogeneity of PTC using single-cell RNA sequencing.
Tian Wang, Chang-ding He, Jian Zhou, Lei Tao   +3 more
doaj   +1 more source