Results 111 to 120 of about 218,906 (301)

Metabolic reprogramming in efferocytosis

Frontiers in Cell and Developmental Biology
Efferocytosis refers to the process by which phagocytes specifically identify and eliminate apoptotic cells. This process is essential for both maintaining tissue homeostasis and suppressing inflammatory responses, as well as facilitating tissue repair ...
Qing Yan, Qing Yan, Kuo Li, Lu Chen, Aowei Wang, Yingying Xi, Hui Xiao, Lei Yuan   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Enumerating all possible biosynthetic pathways from metabolic networks

, 2017
Exhaustive identification of all alternate possible pathways that exist within metabolic networks can provide valuable insights into cellular metabolism.
Aarthi Ravikrishnan, Meghana Nasre, Karthik Raman   +2 more
core   +1 more source

Multi-membership gene regulation in pathway based microarray analysis [PDF]

, 2011
This article is available through the Brunel Open Access Publishing Fund. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use,
Payne, AM, Pavlidis Stelios P, Swift Stephen M, Stephen M Swift, Pavlidis, SP, Payne Annette M, Swift, SM, Annette M Payne, Stelios P Pavlidis   +8 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

What can causal networks tell us about metabolic pathways? [PDF]

, 2011
Graphical models describe the linear correlation structure of data and have been used to establish causal relationships among phenotypes in genetic mapping populations. Data are typically collected at a single point in time.
Gary A Churchill, Gary A. Churchill (173030), Kliebenstein Daniel J., Daniel J. Kliebenstein, Churchill, Gary A, Blair, Rachael Hageman, Rachael Hageman Blair (173017), Churchill Gary A., Rachael Hageman Blair, Daniel J Kliebenstein, Gary A. Churchill, Daniel J. Kliebenstein (173023), Kliebenstein, Daniel J, Blair Rachael Hageman   +13 more
core   +1 more source

Genome-scale metabolic modelling identifies reactions mediated by SNP-SNP interactions associated with yeast sporulation

npj Systems Biology and Applications
Genome-scale metabolic models (GEMs) are powerful tools used to understand the functional effects of genetic variants. However, the impact of single nucleotide polymorphisms (SNPs) in transcription factors and their interactions on metabolic fluxes ...
Srijith Sasikumar, S Pavan Kumar, Nirav Pravinbhai Bhatt, Himanshu Sinha   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Microalgal Metabolic Network Model Refinement through High Throughput Functional Metabolic Profiling

Frontiers in Bioengineering and Biotechnology, 2014
Metabolic modeling provides the means to define metabolic processes at a systems level; however, genome-scale metabolic models often remain incomplete in their description of metabolic networks and may include reactions that are experimentally unverified.
Amphun eChaiboonchoe, Bushra Saeed Dohai, Hong eCai, David R Nelson, Kenan eJijakli, Kenan eJijakli, Kourosh eSalehi-Ashtiani   +6 more
doaj   +1 more source