Results 91 to 100 of about 374,876 (335)

An enzyme activation network provides evidence for extensive regulatory crosstalk between metabolic pathways [PDF]

, 2023
Sultana Mohammed Al Zubaidi, Muhammad Ibtisam Nasar, Markus Ralser, Richard A. Notebaart, Mohammad Tauqeer Alam   +4 more
openalex   +1 more source

HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread [PDF]

, 2016
open access articleHIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the ...
Jolly, Clare, Len, Alice C.L., Shivkumar, Maitreyi, Starling, Shimona   +3 more
core   +2 more sources

Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design [PDF]

BMC Systems Biology, 2010
AbstractBackgroundMicrobial hosts offer a number of unique advantages when used as production systems for both native and heterologous small-molecules. These advantages include high selectivity and benign environmental impact; however, a principal drawback is low yield and/or productivity, which limits economic viability. Therefore a major challenge in
Boghigian, Brett A, Shi, Hai, Lee, Kyongbum, Pfeifer, Blaine A   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modeling cancer metabolism on a genome scale [PDF]

, 2015
Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton, Eyal Gottlieb, Eytan Ruppin, Keren Yizhak, Kiuru M, Li L, Lobo C, Som P, Vazquez‐Martin A   +8 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

Scientific Reports, 2022
Metabolic regulation in skeletal muscle is essential for blood glucose homeostasis. Obesity causes insulin resistance in skeletal muscle, leading to hyperglycemia and type 2 diabetes.
Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, Yunfan Bai, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Hiroyuki Kubota, Yutaka Suzuki, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda   +23 more
doaj   +1 more source

Complex networks theory for analyzing metabolic networks

, 2006
One of the main tasks of post-genomic informatics is to systematically investigate all molecules and their interactions within a living cell so as to understand how these molecules and the interactions between them relate to the function of the organism,
A. B. Horne, A. Bairoch, A. Broder, A. L. Barabasi, A. L. Barabasi, A. Samal, A. Wagner, B. M. Bakker, C. H. Schilling, C. Wagner, D. J. Watts, E. Ravasz, H. Jeong, H. Kitano, H. Lipson, H. W. Ma, H. W. Ma, H. W. Ma, Hong Yu, J. A. Papin, J. C. M. Mombach, J. Gagneur, J. Stelling, J. Stelling, Jianhua Luo, Jing Zhao, L. H. Hartwell, M. Arita, M. C. Palumbo, M. Faloutsos, M. Kanehisa, M. Kanehisa, M. Nakao, M. V. Martinov, N. Lemke, P. D. Karp, P. D. Karp, P. Erdös, P. Holme, R. Albert, R. Guimera, R. Mahadevan, R. Overbeek, R. Schuster, S. Goto, S. Schuster, S. Schuster, S. Wuchty, Yixue Li, Z. N. Oltvai, Z. W. Cao   +50 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source