Results 91 to 100 of about 218,906 (301)

Representing and analysing molecular and cellular function in the computer

, 2000
Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era.
Naim, A., Helden, J., Van, Wernisch, L, Eldridge, M, Wodak, S. J., Gilbert, D, Mancuso, R, Helden, JV, Wodak, SJ, Helden, J.,, Wernisch, Lorenz, Naim, A, Wernisch, L., Eldridge, Matthew, van Helden, Jacques, Mancuso, R., Wodak, Shoshana, Eldridge, M., Mancuso, Renato, Gilbert, D.   +19 more
core   +1 more source

Finding minimal generating set for metabolic network with reversible pathways [PDF]

Biosystems, 2013
Elementary flux modes give a mathematical representation of metabolic pathways in metabolic networks satisfying the constraint of non-decomposability. The large cost of their computation shifts attention to computing a minimal generating set which is a conically independent subset of elementary flux modes.
Dimitrije Jevremovic, Daniel Boley
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A single-cell network approach to decode metabolic regulation in gynecologic and breast cancers

npj Systems Biology and Applications
Cancer metabolism is characterized by significant heterogeneity, presenting challenges for treatment efficacy and patient outcomes. Understanding this heterogeneity and its regulatory mechanisms at single-cell resolution is crucial for developing ...
Akansha Srivastava, P. K. Vinod
doaj   +1 more source

The Dual Role of Autophagy in Lung Cancer: From Molecular Mechanisms to Metabolic Regulation and Targeted Therapy Strategies

Frontiers in Bioscience-Landmark
Lung cancer remains the leading cause of cancer-related mortality worldwide, with five-year survival rates below 20%, underscoring the importance of understanding key biological processes like autophagy in this disease.
Yuxin Men, Jie Chen, Hong Cai, Chunhui Yang   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Predicting metabolic pathways from metabolic networks

, 2012
published_or_final_version ; Computer Science ; Master ; Master of ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Metabolism and Metabolic Reprogramming in Laryngeal Squamous Cell Carcinoma

Biomedicines
Laryngeal squamous cell carcinoma (LSCC) remains a major clinical challenge within head and neck oncology, with five-year survival rates showing minimal improvement over recent decades despite advances in surgical and multimodal therapeutic strategies ...
Barbara Verro, Roberta Oliveri, Giovanni Pratelli, Marianna Lauricella, Diana Di Liberto, Anna De Blasio, Daniela Carlisi, Carmelo Saraniti   +7 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source