Results 81 to 90 of about 218,906 (301)

Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential

Frontiers in Cell and Developmental Biology, 2020
Proton-coupled monocarboxylate transporters (MCTs), representing the first four isoforms of the SLC16A gene family, mainly participate in the transport of lactate, pyruvate, and other monocarboxylates.
Xiangyu Sun, Mozhi Wang, Mengshen Wang, Litong Yao, Xinyan Li, Haoran Dong, Meng Li, Tie Sun, Xing Liu, Yang Liu, Yingying Xu   +10 more
doaj   +1 more source

In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

Scientific Reports, 2022
Metabolic regulation in skeletal muscle is essential for blood glucose homeostasis. Obesity causes insulin resistance in skeletal muscle, leading to hyperglycemia and type 2 diabetes.
Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, Yunfan Bai, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Hiroyuki Kubota, Yutaka Suzuki, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda   +23 more
doaj   +1 more source

Systems biology of the metabolic network regulated by the Akt pathway

Biotechnology Advances, 2012
Cancer has been proposed as an example of systems biology disease or network disease. Accordingly, tumor cells differ from their normal counterparts more in terms of intracellular network dynamics than single markers. Here we shall focus on a recently recognized hallmark of cancer, the deregulation of cellular energetics. The constitutive activation of
E. Mosca, M. Barcella, R. Alfieri, A. Bevilacqua, G. Canti, L. Milanesi   +5 more
openaire   +4 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Maria E Merlo, Wellington Elizabeth MH, David A Hodgson, Breitling, Rainer, Breitling, R., Hodgson, David A.,, Breitling, Rainer,, Breitling, R, Breitling Rainer, Merlo, Maria E., Wellington, Elizabeth M H, Wellington, EMH, Merlo, Maria E.,, Mohammad T Alam, Eriko Takano, Hodgson, D.A., Takano, Eriko,, Hodgson, David A., Alam, M.T., Takano Eriko, Hodgson, D. A., STREAM Consortium, Alam, Mohammad T.,, Takano, E, Takano, E., Merlo, ME, Rainer Breitling, Hodgson, DA, Wellington, Elizabeth M. H., Wellington, Elizabeth M.H.,, Merlo, M.E., Wellington, E.M.H., Alam, Mohammad T., Alam, MT, Alam Mohammad T, Takano, Eriko, Merlo Maria E, Elizabeth MH Wellington, HASH(0x55a67fd0c960), Hodgson David A, Wellington, E. M. H., Takano, Eriko; id_orcid, Merlo, Maria E.; id_orcid, The STREAM Consortium (stream)   +43 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

BioNessie - a grid enabled biochemical networks simulation environment [PDF]

, 2008
The simulation of biochemical networks provides insight and understanding about the underlying biochemical processes and pathways used by cells and organisms.
Gu, Xu, Gilbert, David, Ajayi, Oluwafemi, Ajayi, O., Jiang, Jipu, Gu, X., SINNOTT, RICHARD, Jiang, J., Sinnott, R.O., Liu, X., Gilbert, D., LIU, XUAN   +11 more
core  

A markov classification model for metabolic pathways

Algorithms for Molecular Biology, 2010
Background This paper considers the problem of identifying pathways through metabolic networks that relate to a specific biological response. Our proposed model, HME3M, first identifies frequently traversed network paths using a Markov mixture model ...
Mamitsuka Hiroshi, Hancock Timothy
doaj   +1 more source

Rearrangements of the transcriptional regulatory networks of metabolic pathways in fungi

Current Opinion in Microbiology, 2009
Growing evidence suggests that transcriptional regulatory networks in many organisms are highly flexible. Here, we discuss the evolution of transcriptional regulatory networks governing the metabolic machinery of sequenced ascomycetes. In particular, recent work has shown that transcriptional rewiring is common in regulons controlling processes such as
Lavoie, Hugo, Hogues, Hervé, Whiteway, Malcolm   +2 more
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source