Results 61 to 70 of about 241,688 (237)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Metabolism and Metabolic Reprogramming in Laryngeal Squamous Cell Carcinoma

Biomedicines
Laryngeal squamous cell carcinoma (LSCC) remains a major clinical challenge within head and neck oncology, with five-year survival rates showing minimal improvement over recent decades despite advances in surgical and multimodal therapeutic strategies ...
Barbara Verro, Roberta Oliveri, Giovanni Pratelli, Marianna Lauricella, Diana Di Liberto, Anna De Blasio, Daniela Carlisi, Carmelo Saraniti   +7 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A single-cell network approach to decode metabolic regulation in gynecologic and breast cancers

npj Systems Biology and Applications
Cancer metabolism is characterized by significant heterogeneity, presenting challenges for treatment efficacy and patient outcomes. Understanding this heterogeneity and its regulatory mechanisms at single-cell resolution is crucial for developing ...
Akansha Srivastava, P. K. Vinod
doaj   +1 more source

Metabolic Reprogramming in Thyroid Cancer [PDF]

Endocrinology and Metabolism
Thyroid cancer is a common endocrine malignancy with increasing incidence globally. Although most cases can be treated effectively, some cases are more aggressive and have a higher risk of mortality.
Sang-Hyeon Ju, Minchul Song, Joung Youl Lim, Yea Eun Kang, Hyon-Seung Yi, Minho Shong   +5 more
doaj   +1 more source

Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival [PDF]

, 2011
Hypoxia is one of the features of poorly vascularised areas of solid tumours but cancer cells can survive in these areas despite the low oxygen tension.
Tennant, D.A., Zheng, L, Appanna, VD, Watson David G., Kalna, G., Hedley Barbara A., Papkovsky, Dmitri B, Gottlieb Eyal, Papkovsky, D.B., Christian Frezza, Dmitri B. Papkovsky, Frezza, Christian, Hedley, Barbara A, Zheng Liang, Liang Zheng, Hedley, BA, Watson, DG, Kalna, Gabriela, Dmitri B Papkovsky, Tennant, Daniel A., Gabriela Kalna, Frezza, C, Watson, David, Eyal Gottlieb, Tennant Daniel A., Gottlieb, Eyal, Gottlieb, E., David G. Watson, Frezza Christian, Kalna Gabriela, Hedley, B., Daniel A Tennant, Frezza, C., Kalna, G, Barbara A. Hedley, Zheng, L., Barbara A Hedley, Tennant, Daniel; id_orcid, Gottlieb, E, David G Watson, Papkovsky, DB, Papkovsky Dmitri B., Zheng, Liang, Watson, D.G., Daniel A. Tennant   +44 more
core   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The correlation between the central carbon metabolic flux distribution and the number of shared enzyme regulators in Saccharomyces cerevisiae

Brazilian Archives of Biology and Technology, 2016
The central carbon metabolic system is the upstream energy source for microbial fermentation. In addition, it is a master switch for increasing the production of metabolites and an important part of the microbial metabolic network. Investigation into the
Xiangfei Zhou, Lunxian Liu, Chuanyu Shang, Haifeng Xu, Chao Ding, Qian Liu, Yin Yi   +6 more
doaj   +1 more source