Results 61 to 70 of about 218,906 (301)

Characterization of growth and metabolism of the haloalkaliphile Natronomonas pharaonis [PDF]

, 2010
Natronomonas pharaonis is an archaeon adapted to two extreme conditions: high salt concentration and alkaline pH. It has become one of the model organisms for the study of extremophilic life.
Tanja Oberwinkler, Mendoza, Eduardo, Oesterhelt, Dieter, Ralf Zimmer, Zimmer, R., Dieter Oesterhelt, Pfeiffer Friedhelm, Gonzalez, O., Orland Gonzalez, Oberwinkler Tanja, Pfeiffer, F., Zimmer, Ralf, Zimmer Ralf, Pfeiffer, Friedhelm, Mansueto, L., Oesterhelt Dieter, Mansueto, Locedie, Mendoza Eduardo, Gonzalez Orland, Mansueto Locedie, Oberwinkler, T., Mendoza, E., Gonzalez, Orland, Oesterhelt, D., Locedie Mansueto, Eduardo Mendoza, Oberwinkler, Tanja, Friedhelm Pfeiffer   +27 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways [PDF]

, 2018
Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms.
Pollak, Nina M., Hoffman, Matthew, Drosatos, Konstantinos, Goldberg, Ira J., 0000-0003-0903-834X   +4 more
core   +1 more source

Analysis on relationship between extreme pathways and correlated reaction sets

BMC Bioinformatics, 2009
Background Constraint-based modeling of reconstructed genome-scale metabolic networks has been successfully applied on several microorganisms. In constraint-based modeling, in order to characterize all allowable phenotypes, network-based pathways, such ...
Wang Weirong, Cao Ming, Chen Yi-Ping, Xi Yanping, Wang Fei   +4 more
doaj   +1 more source

Drawing oriented metabolic pathways and networks [PDF]

Traditionally, metabolic pathways have been depicted manually or semi-automatically, a process that is often time-consuming and requires substantial manual adjustments. As biological data has expanded exponentially, the need for more scalable and comprehensible visualisation methods has become increasingly important.
Pérez Guerrero, Laura Hui
openaire   +2 more sources

Pathway identification by network pruning in the metabolic network of Escherichia coli [PDF]

Bioinformatics, 2009
Abstract Motivation: All metabolic networks contain metabolites, such as ATP and NAD, known as currency metabolites, which take part in many reactions. These are often removed in the study of these networks, but no consensus exists on what actually constitutes a currency metabolite, and it is also unclear how these highly connected nodes
Philip Gerlee, L. Lizana, Kim Sneppen
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Network structure of metabolic pathways

Journal of Biological Physics and Chemistry, 2001
networks (or graphs) consist of nodes and links between them. The number of links per node, which we call the class of the node, may vary between nodes, but in a homogeneous network the statistical distribution of links will be the same from region to region across the network.
openaire   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source