Results 61 to 70 of about 374,876 (335)

Cancer metabolism: a modeling perspective

Frontiers in Physiology, 2015
Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant on constant supply of nutrients and energy.
Pouyan eGhaffari Nouran, Adil eMardinoglu, Adil eMardinoglu, Jens eNielsen, Jens eNielsen, Jens eNielsen   +5 more
doaj   +1 more source

Genome-Wide Association Study of Metabolic Syndrome in Koreans [PDF]

Genomics & Informatics, 2014
Metabolic syndrome (METS) is a disorder of energy utilization and storage and increases the risk of developing cardiovascular disease and diabetes. To identify the genetic risk factors of METS, we carried out a genome-wide association study (GWAS) for 2 ...
Seok Won Jeong, Myungguen Chung, Soo-Jung Park, Seong Beom Cho, Kyung-Won Hong   +4 more
doaj   +1 more source

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle [PDF]

, 2015
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production.
CAPUANI, FABRIZIO, DE MARTINO, ANDREA, DE MARTINO, DANIELE, MARINARI, Vincenzo   +3 more
core   +1 more source

CircRNA-Associated ceRNA Network Reveals Focal Adhesion and Metabolism Pathways in Neuropathic Pain

Journal of Oncology, 2022
Background. Increasing evidence has shown that noncoding RNAs perform a remarkable function in neuropathic pain (NP); nonetheless, the mechanisms underlying the modulation of competitive endogenous RNA in NP remain uncertain. The goal of this research was to investigate the molecular processes underlying NP. Methods.
Kun Wang, Jun-Ping Bao, Zhi-Min Zhou, Lu Mao, Xiao-Tao Wu   +4 more
openaire   +2 more sources

MicroRNA regulation of bovine monocyte inflammatory and metabolic networks in an in vivo infection model. [PDF]

, 2014
peer-reviewedBovine mastitis is an inflammation-driven disease of the bovine mammary gland that costs the global dairy industry several billion dollars per annum.
Baker, Mike, Bryan, Kenneth, Lawless, Nathan, Lippolis, John D., Lynn, David J, O'Farrelly, Cliona, Pesch, Bruce, Reinhardt, Timothy A., Sonstegard, Tad, Zimmerman, Duane, Zuelke, Kurt   +10 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential

Frontiers in Cell and Developmental Biology, 2020
Proton-coupled monocarboxylate transporters (MCTs), representing the first four isoforms of the SLC16A gene family, mainly participate in the transport of lactate, pyruvate, and other monocarboxylates.
Xiangyu Sun, Mozhi Wang, Mengshen Wang, Litong Yao, Xinyan Li, Haoran Dong, Meng Li, Tie Sun, Xing Liu, Yang Liu, Yingying Xu   +10 more
doaj   +1 more source

Modeling tissue‐relevant Caenorhabditis elegans metabolism at network, pathway, reaction, and metabolite levels

Molecular Systems Biology, 2020
Metabolism is a highly compartmentalized process that provides building blocks for biomass generation during development, homeostasis, and wound healing, and energy to support cellular and organismal processes. In metazoans, different cells and tissues specialize in different aspects of metabolism.
Lutfu Safak Yilmaz, Xuhang Li, Shivani Nanda, Bennett Fox, Frank Schroeder, Albertha JM Walhout   +5 more
openaire   +4 more sources

Global connectivity in genome-scale metabolic networks revealed by comprehensive FBA-based pathway analysis

BMC Microbiology, 2021
Background Graph-based analysis (GBA) of genome-scale metabolic networks has revealed system-level structures such as the bow-tie connectivity that describes the overall mass flow in a network.
Yajie Gao, Qianqian Yuan, Zhitao Mao, Hao Liu, Hongwu Ma   +4 more
doaj   +1 more source

Gut microbiota alterations in critically Ill patients with carbapenem-resistant Enterobacteriaceae colonization: A clinical analysis

Frontiers in Microbiology, 2023
BackgroundCarbapenem-resistant Enterobacteriaceae (CRE) are an emerging concern for global health and are associated with high morbidity and mortality in critically ill patients.
Moon Seong Baek, Seungil Kim, Won-Young Kim, Mi-Na Kweon, Jin Won Huh   +4 more
doaj   +1 more source