Results 41 to 50 of about 374,876 (335)

Peritoneal dialysis influences microRNA expression and pro-inflammatory response: results from a cross-sectional study [PDF]

Brazilian Journal of Nephrology
Introduction: The investigation of circulating microRNAs (miRNAs) and inflammatory response associated with the different stages of chronic kidney disease (CKD) may reveal biomarkers of disease pathogenesis. Our goal was to identifying differences in the
Nara Aline Costa, Amanda Gomes Pereira, Hellen Christina Neves Rodrigues, Lilian Cuppari, Tainara Francini Felix, Iael Weissberg Minutentag, Patricia Pintor Reis, André Luis Balbi, Bertha Furlan Polegato, Paula Schmidt Azevedo, Leonardo Antonio Mamede Zornoff, Sérgio Alberto Rupp de Paiva, Daniela Ponce, Marcelo Macedo Rogero, Marcos Ferreira Minicucci   +14 more
doaj   +1 more source

Chemical Transformation Motifs - Modelling Pathways as Integer Hyperflows [PDF]

, 2017
We present an elaborate framework for formally modelling pathways in chemical reaction networks on a mechanistic level. Networks are modelled mathematically as directed multi-hypergraphs, with vertices corresponding to molecules and hyperedges to ...
Andersen, Jakob L., Flamm, Christoph, Merkle, Daniel, Stadler, Peter F.   +3 more
core   +2 more sources

Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways

Microbiology Spectrum, 2021
Fungal secondary metabolites are widely used as therapeutics and are vital components of drug discovery programs. A major challenge hindering discovery of novel secondary metabolites is that the underlying pathways involved in their biosynthesis are ...
Min Jin Kwon, Charlotte Steiniger, Timothy C. Cairns, Jennifer H. Wisecaver, Abigail L. Lind, Carsten Pohl, Carmen Regner, Antonis Rokas, Vera Meyer   +8 more
doaj   +1 more source

Metabolic Reprogramming in Triple-Negative Breast Cancer

Frontiers in Oncology, 2020
Metabolic reprogramming is an emerging hallmark of cancer cells, in which cancer cells exhibit distinct metabolic phenotypes to fuel their proliferation and progression.
Xiangyu Sun, Mozhi Wang, Mengshen Wang, Xueting Yu, Jingyi Guo, Tie Sun, Xinyan Li, Litong Yao, Haoran Dong, Yingying Xu   +9 more
doaj   +1 more source

Functional prediction of environmental variables using metabolic networks

Scientific Reports, 2021
In this manuscript, we propose a novel approach to assess relationships between environment and metabolic networks. We used a comprehensive dataset of more than 5000 prokaryotic species from which we derived the metabolic networks.
Adèle Weber Zendrera, Nataliya Sokolovska, Hédi A. Soula   +2 more
doaj   +1 more source

The Metabolic Phenotype of Prostate Cancer

Frontiers in Oncology, 2017
Prostate cancer is the most common non-cutaneous cancer in men in the United States. Cancer metabolism has emerged as a contemporary topic of great interest for improved mechanistic understanding of tumorigenesis.
Eric Eidelman, Jeffrey Twum-Ampofo, Jamal Ansari, Mohummad Minhaj Siddiqui, Mohummad Minhaj Siddiqui, Mohummad Minhaj Siddiqui   +5 more
doaj   +1 more source

Alterations in cellular metabolism under different grades of glioma staging identified based on a multi-omics analysis strategy

Frontiers in Endocrinology, 2023
Glioma is a type of brain tumor closely related to abnormal cell metabolism. Firstly, multiple combinatorial sequencing studies have revealed this relationship.
Xianlei Yan, Xianlei Yan, Jinwei Li, Yang Zhang, Cong Liang, Pengcheng Liang, Tao Li, Quan Liu, Xuhui Hui   +8 more
doaj   +1 more source

On functional module detection in metabolic networks [PDF]

, 2013
Functional modules of metabolic networks are essential for understanding the metabolism of an organism as a whole. With the vast amount of experimental data and the construction of complex and large-scale, often genome-wide, models, the computer-aided ...
Adleman, Backhaus, Berthelot, Berthelot, Billington, Bortfeldt, Colom, Cormen, Deuflhard, Durbin, Farkas, Fourier, Gardiner, Garey, Grunwald, Haken, Klee, Knuth, Koch, Lipton, Lipton, Murray, Paun, Pérès, Schuster, Shor, Starke, Steinhausen, Su, Zhou   +29 more
core   +2 more sources

What do we learn from correlations of local and global network properties? [PDF]

, 2006
In complex networks a common task is to identify the most important or "central" nodes. There are several definitions, often called centrality measures, which often lead to different results.
Albert, Alexander K. Hartmann, Barabási, Barabási, Barrat, Bernd Burghardt, Bollobás, Brockmann, Caldarelli, Demetrius, Erdös, Erdös, Erdös, Estrada, Estrada, Fenner, Freeman, Freeman, Goh, Goh, Holme, Kaiser, Kim, Kim, Ma, Magnus Jungsbluth, Masucci, Middendorf, Newman, Newman, Newman, Park, Ramasco, Saramäki, Scott, Vazquez, Vazquez, Volchenkov, Watts, Watts, Watts, Xuan, Zhou   +42 more
core   +2 more sources

Advances in network-based metabolic pathway analysis and gene expression data integration [PDF]

Briefings in Bioinformatics, 2014
With the emergence of metabolic networks, novel mathematical pathway concepts were introduced in the past decade, aiming to go beyond canonical maps. However, the use of network-based pathways to interpret 'omics' data has been limited owing to the fact that their computation has, until very recently, been infeasible in large (genome-scale) metabolic ...
Alberto, Rezola, Jon, Pey, Luis, Tobalina, Ángel, Rubio, John E, Beasley, Francisco J, Planes   +5 more
openaire   +2 more sources