Results 21 to 30 of about 218,906 (301)

Pathway discovery in metabolic networks by subgraph extraction [PDF]

open access: yesBioinformatics, 2010
Abstract Motivation: Subgraph extraction is a powerful technique to predict pathways from biological networks and a set of query items (e.g. genes, proteins, compounds, etc.). It can be applied to a variety of different data types, such as gene expression, protein levels, operons or phylogenetic profiles.
Karoline Faust   +3 more
openaire   +4 more sources

Pathway Tools Visualization of Organism-Scale Metabolic Networks [PDF]

open access: yesMetabolites, 2021
Metabolomics, synthetic biology, and microbiome research demand information about organism-scale metabolic networks. The convergence of genome sequencing and computational inference of metabolic networks has enabled great progress toward satisfying that demand by generating metabolic reconstructions from the genomes of thousands of sequenced organisms.
Suzanne Paley   +4 more
openaire   +3 more sources

Evolution under Fluctuating Environments Explains Observed Robustness in Metabolic Networks [PDF]

open access: yes, 2010
Copyright: © 2010 Soyer, Pfeiffer. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Pfeiffer, Thomas   +6 more
core   +1 more source

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. [PDF]

open access: yes, 2014
The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions.
Opperdoes, F.R. (Fred)   +249 more
core   +1 more source

Role of Ferroptosis in Lung Diseases

open access: yesJournal of Inflammation Research, 2021
Wenting Xu,1,2,* Huimin Deng,2,* Song Hu,2,3,* Yiguo Zhang,2,3 Li Zheng,1,2 Meiyun Liu,2 Yuanli Chen,2 Juan Wei,2 Hao Yang,2 Xin Lv1– 3 1Department of Anesthesiology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, 236000, People&rsquo ...
Xu W   +9 more
doaj  

Peritoneal dialysis influences microRNA expression and pro-inflammatory response: results from a cross-sectional study [PDF]

open access: yesBrazilian Journal of Nephrology
Introduction: The investigation of circulating microRNAs (miRNAs) and inflammatory response associated with the different stages of chronic kidney disease (CKD) may reveal biomarkers of disease pathogenesis. Our goal was to identifying differences in the
Nara Aline Costa   +14 more
doaj   +1 more source

Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways

open access: yesMicrobiology Spectrum, 2021
Fungal secondary metabolites are widely used as therapeutics and are vital components of drug discovery programs. A major challenge hindering discovery of novel secondary metabolites is that the underlying pathways involved in their biosynthesis are ...
Min Jin Kwon   +8 more
doaj   +1 more source

Systems approaches to modelling pathways and networks. [PDF]

open access: yes, 2011
Peer ...
Christian, Nils   +5 more
core   +1 more source

On Algebraic Properties of Extreme Pathways in Metabolic Networks

open access: yesJournal of Computational Biology, 2010
We give a concise development of some of the major algebraic properties of extreme pathways (pathways that cannot be the result of combining other pathways) of metabolic networks, contrasting them to those of elementary flux modes (pathways involving a minimal set of reactions). In particular, we show that an extreme pathway can be recognized by a rank
Dimitrije Jevremovic   +3 more
openaire   +3 more sources

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

open access: yes, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
Kierzek, A.M.   +36 more
core   +1 more source

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