Results 11 to 20 of about 218,906 (301)

Alterations in metabolic pathways and networks in Alzheimer’s disease [PDF]

Translational Psychiatry, 2013
The pathogenic mechanisms of Alzheimer's disease (AD) remain largely unknown and clinical trials have not demonstrated significant benefit. Biochemical characterization of AD and its prodromal phase may provide new diagnostic and therapeutic insights.
Kaddurah-Daouk, R., Zhu, H., Sharma, S., Bogdanov, M., Rozen, S.G., Matson, W., Oki, N.O., Motsinger-Reif, A.A., Churchill, E., Lei, Z., Appleby, D., Kling, M.A., Trojanowski, J.Q., Doraiswamy, P.M., Arnold, S.E.   +14 more
openaire   +2 more sources

Leveraging heterogeneous network embedding for metabolic pathway prediction [PDF]

Bioinformatics, 2020
Abstract Motivation Metabolic pathway reconstruction from genomic sequence information is a key step in predicting regulatory and functional potential of cells at the individual, population and community levels of organization.
Basher, Abdur Rahman M. A., Hallam, Steven J.   +1 more
openaire   +2 more sources

Clustering analysis of tumor metabolic networks

BMC Bioinformatics, 2020
Background Biological networks are representative of the diverse molecular interactions that occur within cells. Some of the commonly studied biological networks are modeled through protein-protein interactions, gene regulatory, and metabolic pathways ...
Ichcha Manipur, Ilaria Granata, Lucia Maddalena, Mario R. Guarracino   +3 more
doaj   +1 more source

MetNet: A two-level approach to reconstructing and comparing metabolic networks.

PLoS ONE, 2021
Metabolic pathway comparison and interaction between different species can detect important information for drug engineering and medical science. In the literature, proposals for reconstructing and comparing metabolic networks present two main problems ...
Nicoletta Cocco, Mercè Llabrés, Mariana Reyes-Prieto, Marta Simeoni   +3 more
doaj   +1 more source

A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression

Biomedicines, 2022
The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the immune system, and (ii) to ...
Diego A. Bonilla, Yurany Moreno, Jorge L. Petro, Diego A. Forero, Salvador Vargas-Molina, Adrián Odriozola-Martínez, Carlos A. Orozco, Jeffrey R. Stout, Eric S. Rawson, Richard B. Kreider   +9 more
doaj   +1 more source

Pathways and fluxes: exploring the plant metabolic network [PDF]

Journal of Experimental Botany, 2012
The transition from a pathway-centred view of plant metabolism to a network-wide perspective is still incomplete. Further progress in this direction requires tools to facilitate the structural description of the network on the basis of fully annotated genomes, techniques for modelling the properties of the network, and experimental methods for ...
Kruger, N, Ratcliffe, R
openaire   +2 more sources

The link between ferroptosis and airway inflammatory diseases: A novel target for treatment

Frontiers in Molecular Biosciences, 2022
Ferroptosis is an iron-dependent mode of cell death characterized by intracellular lipid peroxide accumulation and a redox reaction imbalance. Compared with other modes of cell death, ferroptosis has specific biological and morphological features.
Zhiwei Lin, Xiaojing Yang, Lili Guan, Lijie Qin, Jiabin Ding, Luqian Zhou   +5 more
doaj   +1 more source

Estimation of the number of extreme pathways for metabolic networks [PDF]

BMC Bioinformatics, 2007
Abstract Background The set of extreme pathways (ExPa), {p i }, defines the convex basis vectors used for the mathematical characterization of the null space of the stoichiometric matrix for biochemical reaction networks.
Matthew Yeung, Ines Thiele, Bernhard O. Palsson   +2 more
openaire   +4 more sources

Path finding methods accounting for stoichiometry in metabolic networks [PDF]

, 2011
Copyright © 2011 Pey et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution ...
Prada, J, Francisco J Planes, Joaquín Prada, Beasley, JE, Pey, J, John E Beasley, Pey, Jon, Prada, Joaquin, Jon Pey, Planes, Francisco J, Planes, FJ, Beasley, John E   +11 more
core   +1 more source

Benchmarking procedures for high-throughput context specific reconstruction algorithms

Frontiers in Physiology, 2016
Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information.
Maria ePires Pacheco, Thomas ePfau, Thomas eSauter   +2 more
doaj   +1 more source