Results 51 to 60 of about 218,906 (301)

Gut microbiota alterations in critically Ill patients with carbapenem-resistant Enterobacteriaceae colonization: A clinical analysis

Frontiers in Microbiology, 2023
BackgroundCarbapenem-resistant Enterobacteriaceae (CRE) are an emerging concern for global health and are associated with high morbidity and mortality in critically ill patients.
Moon Seong Baek, Seungil Kim, Won-Young Kim, Mi-Na Kweon, Jin Won Huh   +4 more
doaj   +1 more source

Inferring branching pathways in genome-scale metabolic networks [PDF]

BMC Systems Biology, 2009
A central problem in computational metabolic modelling is how to find biochemically plausible pathways between metabolites in a metabolic network. Two general, complementary frameworks have been utilized to find metabolic pathways: constraint-based modelling and graph-theoretical path finding approaches.
Esa Pitkänen, Paula Jouhten, Juho Rousu
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Comparative Pathway Analyzer - a web server for comparative analysis, clustering and visualization of metabolic networks in multiple organisms

, 2008
Oehm S, Gilbert D, Tauch A, Stoye J, Goesmann A. Comparative Pathway Analyzer - a web server for comparative analysis, clustering and visualization of metabolic networks in multiple organisms. NUCLEIC ACIDS RESEARCH.
Gilbert, David, Oehm, S, Tauch, Andreas, Stoye, Jens ; https://orcid.org/, Gilbert, D, Tauch, A, Goesmann, A, Goesmann, Alexander ; https://orcid.org/, Stoye, J, Oehm, Sebastian   +9 more
core   +1 more source

Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions [PDF]

, 2011
Background: Stable isotope tracers are used to assess metabolic flux profiles in living cells. The existing methods of measurement average out the isotopic isomer distribution in metabolites throughout the cell, whereas the knowledge of compartmental ...
Marin, Silvia, Loranne Agius, Selivanov, Vitaly, Marta Cascante, Roca Elias, Josep, Oresic, Matej, Cascante i Serratosa, Marta, Cascante, Marta, Igor Marin de Mas, Josep Roca, Marín Martínez, Silvia, Selivanov, Vitaly A., de Mas, Igor Marin, Silvia Marin, Agius, Loranne, Vitaly A Selivanov, Matej Orešič, Marín de Mas, Igor Bartolomé, Roca, Josep   +18 more
core   +1 more source

Global connectivity in genome-scale metabolic networks revealed by comprehensive FBA-based pathway analysis

BMC Microbiology, 2021
Background Graph-based analysis (GBA) of genome-scale metabolic networks has revealed system-level structures such as the bow-tie connectivity that describes the overall mass flow in a network.
Yajie Gao, Qianqian Yuan, Zhitao Mao, Hao Liu, Hongwu Ma   +4 more
doaj   +1 more source

Inferring qualitative relations in genetic networks and metabolic pathways [PDF]

Bioinformatics, 2000
Abstract Motivation: Inferring genetic network architecture from time series data of gene expression patterns is an important topic in bioinformatics. Although inference algorithms based on the Boolean network were proposed, the Boolean network was not sufficient as a model of a genetic network.
Tatsuya Akutsu, Satoru Miyano, Satoru Kuhara   +2 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Alignment of Linear Biochemical Pathways Using Protein Structural Classification

, 2008
Metabolic, signaling and regulatory pathways form the basis of biological processes and are important for the analysis of cellular behavior and evolution.
Timm Oberwahrenbrock, Töpel, Thoralf, Thoralf Töpel, Hofestädt, Ralf, Ralf Hofestädt, Oberwahrenbrock, T., Hariharaputran, Sridhar, Sridhar Hariharaputran   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source