Results 131 to 140 of about 218,906 (301)

Metallic molybdenum sulfide catalyses protometabolic carbon dioxide reaction networks under extreme conditions

Nature Communications
The nonenzymatic synthesis of organics from H2–CO2 redox couple forms the foundational basis for prebiotic carbon metabolism. However, constructing comprehensive carbon cycling reaction networks with multiple interlinked subsystems preceding enzymatic ...
Pengfei Chen, Xu Liu, Daoping He, Yiju Liao, Haozhe Li, Jiong Cheng, Yichang Lu, Ziming Yang, Yang Yang, Fangming Jin   +9 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Model simplification of signal transduction pathway networks via a hybrid inference strategy

, 2008
A full-scale mathematical model of cellular networks normally involves a large number of variables and parameters. How to effectively develop manageable and reliable models is crucial for effective computation, analysis and design of such systems.
Hong Yue, Jianfang Jia, Yue, H., Jia, J.F., Yue, Hong, Jia, Jianfang   +5 more
core   +1 more source

Strategy for Exploring Metabolic Pathways: Generation of Hypothetical Metabolic Network

Journal of Computer Science & Systems Biology, 2015
Development of metabolomics has made completion of metabolic map an important issue. Rational suggestion of specific metabolic pathways as candidates for real pathway will promote study to complete metabolic map. Exploring hypothetical metabolic networks containing candidate pathways enable this.
openaire   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Predicting networking couples for metabolic pathways of Arabidopsis

, 2006
EXCLI Journal ; Vol.
Cai, Yu-Dong, Chou, Kuo-Chen, Zhong, Wei-Zhu   +2 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Stoichiometric analysis of self-maintaining metabolisms

, 2008
This paper presents an extension of stoichiometric analysis in systems where the catalytic compounds (enzymes) are also intermediates of the metabolic network (dual property), so they are produced and degraded by the reaction network itself. To take this
Montero, Francisco, Morán, Federico, Olasagasti, Félix, Sanz Nuño, Juan Carlos, Vázquez, Sara, Meléndez-Hévia, Enrique   +5 more
core   +1 more source