Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension. [PDF]
Norzagaray-Valenzuela CD +9 more
europepmc +1 more source
Extreme Pathway Lengths and Reaction Participation in Genome-Scale Metabolic Networks [PDF]
Jason A. Papin +2 more
openalex +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Harnessing glycolysis in gastric cancer: molecular targets, therapeutic strategies, and clinical horizons. [PDF]
Shan Z, Liu Y.
europepmc +1 more source
Complex Interplay of Metabolic Pathways in Grafting of Ziziphus Species: Transcriptomic Insights into Regulatory Networks of Carbohydrates and Secondary Metabolite Biosynthesis [PDF]
Sai‐Yang Zhang +5 more
openalex +1 more source
FluxAnalyzer: exploring structure, pathways, and flux distributions in metabolic networks on interactive flux maps [PDF]
Steffen Klamt +3 more
openalex +1 more source
3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram +5 more
wiley +1 more source
Integrated multi-omics network analysis reveals key metabolic pathways in gastric adenocarcinoma [PDF]
Botao Xu +4 more
openalex +1 more source
A 3D bone scaffold with osteogenic properties and capable of hardening in vivo is developed. The scaffold is implanted in a ductile state, and a phase transformation of the ceramic induces the stiffening and strengthening of the scaffold in vivo. Abstract Calcium phosphate 3D printing has revolutionized customized bone grafting.
Miguel Mateu‐Sanz +7 more
wiley +1 more source
Identification of immunosuppressive CD4<sup>+</sup> T-cell subtype and construction of prognostic model for hepatocellular carcinoma. [PDF]
Wang C +5 more
europepmc +1 more source

