Results 301 to 310 of about 335,580 (367)

The role of programmed cell death in renal cancer: a bibliometric perspective (1998-2024). [PDF]

Discov Oncol
Hong L, Zhao C, Wu T, Hu X, Li X, Li L.
europepmc   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Integrating Metabolomics and Network Analyses to Explore Mechanisms of Geum japonicum var. chinense Against Pulmonary Fibrosis: Involvement of Arachidonic Acid Metabolic Pathway

Junyan Ran, Qian Wang, Tao Lu, Xiuqing Pang, Shang‐Gao Liao, Xun He   +5 more
openalex   +1 more source

A Multi-Modal Graph Neural Network Framework for Parkinson's Disease Therapeutic Discovery. [PDF]

Int J Mol Sci
Akgüller Ö, Balcı MA, Cioca G.
europepmc   +1 more source

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

Advanced Science, EarlyView.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen   +7 more
wiley   +1 more source

Deciphering Important Metabolic Pathways through Reaction Pair Prediction with a Siamese Transformer Network

Han Bao, Xinxin Wang, Jinhui Zhao, Bin Wang, Xinjie Zhao, Chunxia Zhao, Xin Lu, Guowang Xu   +7 more
openalex   +1 more source

Single-cell transcriptomics reveals metabolic remodeling and functional specialization in the immune microenvironment of bone tumors. [PDF]

J Transl Med
Chen J, Cui N, He SH, Xia CY, Li WQ.
europepmc   +1 more source

Accelerated Bone Healing via Electrical Stimulation

Advanced Science, EarlyView.
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun, Wenqing Xie, Yuxiang Wu, Zhou Li, Yusheng Li   +4 more
wiley   +1 more source

Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower. [PDF]

Int J Mol Sci
Wu Z, Hu Y, Hao R, Li R, Lu X, Itale MW, Yuan Y, Zhu X, Zhang J, Wang L, Sun M, Hou X.   +11 more
europepmc   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source