Results 301 to 310 of about 363,947 (345)

Pathway knockout and redundancy in metabolic networks

Journal of Theoretical Biology, 2011
The robustness and stability of complex cellular networks is often attributed to the redundancy of components, including genes, enzymes and pathways. Estimation of redundancy is still an open question in systems biology. Current theoretical tools to measure redundancy have various strengths and shortcomings in providing a comprehensive description of ...
Yong, Min, Xiaogang, Jin, Ming, Chen, Zhengzheng, Pan, Ying, Ge, Jie, Chang   +5 more
openaire   +2 more sources

Metabolite–Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks

Annual Review of Biochemistry, 2018
How individual enzymes evolved is relatively well understood. However, individual enzymes rarely confer a physiological advantage on their own. Judging by its current state, the emergence of metabolism seemingly demanded the simultaneous emergence of many enzymes.
Noda-Garcia, Lianet, Tawfik, Dan, S., Liebermeister, Wolfram   +2 more
openaire   +5 more sources

Text Mining for Metabolic Pathways, Signaling Cascades, and Protein Networks

Science's STKE, 2005
The complexity of the information stored in databases and publications on metabolic and signaling pathways, the high throughput of experimental data, and the growing number of publications make it imperative to provide systems to help the researcher navigate through these interrelated information resources.
Robert, Hoffmann, Martin, Krallinger, Eduardo, Andres, Javier, Tamames, Christian, Blaschke, Alfonso, Valencia   +5 more
openaire   +2 more sources

Metabolic pathway analysis of yeast strengthens the bridge between transcriptomics and metabolic networks

Biotechnology and Bioengineering, 2004
AbstractCentral carbon metabolism of the yeast Saccharomyces cerevisiae was analyzed using metabolic pathway analysis tools. Elementary flux modes for three substrates (glucose, galactose, and ethanol) were determined using the catabolic reactions occurring in yeast.
Tunahan, Cakir, Betül, Kirdar, Kutlu O, Ulgen   +2 more
openaire   +2 more sources

Interaction between Phthalate Ester and Rice Plants: Novel Transformation Pathways and Metabolic-Network Perturbations

Environmental Science & Technology, 2023
Our understanding is limited concerning the interaction mechanism between widespread phthalate esters and staple crops, which have strong implications for human exposure. Therefore, this study was aimed at illuminating the transformation pathways of di-n-butyl phthalate (DnBP) in rice using an untargeted screening method.
Huanhuan Xing, Xiaolong Yu, Jianteng Sun, Guining Lu, Minghan Zhu, Jiahao Liang, Ling Jin, Lizhong Zhu   +7 more
openaire   +2 more sources

The pentose phosphate pathway and organization of metabolic networks enabling growth programs

Current Opinion in Systems Biology, 2021
Abstract ‘The whole is greater than the sum of its parts’, a quote misattributed to Aristotle, is especially true for metabolic networks and the key metabolic reactions within. Here, exemplifying the oxidative and non-oxidative arms of the pentose phosphate pathway (PPP), we separate the roles of key metabolites or precursors generated within, and ...
Zeenat Rashida, Sunil Laxman
openaire   +1 more source