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Metabolic pathway analysis of yeast strengthens the bridge between transcriptomics and metabolic networks

Biotechnology and Bioengineering, 2004
AbstractCentral carbon metabolism of the yeast Saccharomyces cerevisiae was analyzed using metabolic pathway analysis tools. Elementary flux modes for three substrates (glucose, galactose, and ethanol) were determined using the catabolic reactions occurring in yeast.
Tunahan, Cakir   +2 more
openaire   +2 more sources

Interaction between Phthalate Ester and Rice Plants: Novel Transformation Pathways and Metabolic-Network Perturbations

Environmental Science & Technology, 2023
Our understanding is limited concerning the interaction mechanism between widespread phthalate esters and staple crops, which have strong implications for human exposure. Therefore, this study was aimed at illuminating the transformation pathways of di-n-butyl phthalate (DnBP) in rice using an untargeted screening method.
Huanhuan Xing   +7 more
openaire   +2 more sources

The pentose phosphate pathway and organization of metabolic networks enabling growth programs

Current Opinion in Systems Biology, 2021
Abstract ‘The whole is greater than the sum of its parts’, a quote misattributed to Aristotle, is especially true for metabolic networks and the key metabolic reactions within. Here, exemplifying the oxidative and non-oxidative arms of the pentose phosphate pathway (PPP), we separate the roles of key metabolites or precursors generated within, and ...
Zeenat Rashida, Sunil Laxman
openaire   +1 more source

Analysis and visualization of metabolic pathways and networks: A hypegraph approach

IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI), 2014
Metabolic pathways are series of chemical reactions occurring in a cell. Various graph-based models are used to represent metabolic data. However, diverse problems may arise from adopting these models. A more accurate modeling framework can be offered by hypergraphs.
Evaggelia M. Maniadi, Ioannis G. Tollis
openaire   +1 more source

Reconstruction of biological pathways and metabolic networks from in silico labeled metabolites

Biotechnology Journal, 2017
AbstractReaction atom mappings track the positional changes of all of the atoms between the substrates and the products as they undergo the biochemical transformation. However, information on atom transitions in the context of metabolic pathways is not widely available in the literature. The understanding of metabolic pathways at the atomic level is of
Noushin, Hadadi   +3 more
openaire   +2 more sources

From Metabolic Reactions to Networks and Pathways

2011
Enzymatic reactions form a hypergraph structure and their translation into a graph structure accompanies an information loss. This chapter introduces well-known topological transformations from metabolic reactions to a graph, and discusses their advantages and disadvantages. Also discussed is the legitimacy of defining cofactors or currency metabolites,
openaire   +2 more sources

METABOLIC PATHWAY ALIGNMENT (M-PAL) REVEALS DIVERSITY AND ALTERNATIVES IN CONSERVED NETWORKS

Proceedings of the 6th Asia-Pacific Bioinformatics Conference, 2007
We introduce a comparative analysis of metabolic reaction networks between different species. Our method systematically investigates full metabolic networks of multiple species at the same time, with the goal of identifying highly similar yet non-identical pathways which execute the same metabolic function, i.e.
YUNLEI LI   +3 more
openaire   +1 more source

Design of Pathway-Level Bioprocess Monitoring and Control Strategies Supported by Metabolic Networks

2012
In this chapter we explore the basic tools for the design of bioprocess monitoring, optimization, and control algorithms that incorporate a priori knowledge of metabolic networks. The main advantage is that this ultimately enables the targeting of intracellular control variables such as metabolic reactions or metabolic pathways directly linked with ...
Inês A, Isidro   +5 more
openaire   +2 more sources

Visualising Metabolic Pathways and Networks: Past, Present, Future

2021
Falk Schreiber   +3 more
openaire   +1 more source

Investigating Metabolic Pathways and Networks

2019
Md. Altaf-Ul-Amin   +2 more
openaire   +1 more source

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