Results 161 to 170 of about 972,456 (315)

METABOLIC PATHWAYS [PDF]

Neuro-Oncology, 2011
J. W. Locasale, T. Melman, S. S. Song, X. Yang, K. D. Swanson, L. C. Cantley, J. M. Asara, E. T. Wong, S. Adams, N. Braidy, C. Teo, G. Guillemin, M. Philippe, C. Carole, T. David, G. Eric, N.-M. Isabelle, M. de Paula Andre, B. Marylin, C. Olivier, O. L'Houcine, F.-B. Dominique, P. Leukel, C. Seliger, A. Vollmann, B. Jachnik, U. Bogdahn, P. Hau, X. Liu, V. S. Kumar, C. M. McPherson, L. Chow, A. Kendler, B. Dasgupta, S. Piya, E. White, S. Klein, H. Jiang, F. Lang, W. K. Alfred Yung, C. Gomez-Manzano, J. Fueyo, A. Vartanian, A. Guha, K. E. Fenton, M. Abdelwahab, A. C. Scheck, D. Guo, F. Reinitz, M. Youssef, C. Hong, D. Nathanson, D. Akhavan, D. Kuga, A. N. Amzajerdi, H. Soto, S. Zhu, I. Babic, A. Iwanami, K. Tanaka, B. Gini, J. DeJesus, D. D. Lisiero, T. Huang, R. Prins, P. Wen, H. I. Robbins, M. Prados, L. DeAngelis, I. Mellinghoff, M. Mehta, C. D. James, A. Chakravarti, T. Cloughesy, P. Tontonoz, P. Mischel, J. Phillips, J. Mukherjee, C. Cowdrey, J. Wiencke, R. O. Pieper, R. Bachoo, I. Marin-Valencia, S. Cho, D. Rakheja, K. Hatanpaa, T. Mashimo, V. Vemireddy, P. Kapur, L. Good, X. Sun, J. Pascual, M. Takahashi, O. Togao, J. Raisanen, E. A. Maher, R. DeBerardinis, C. Malloy, E. A. Maher, R. Bachoo, I. Marin-Valencia, K. Hatanpaa, C. Choi, T. Mashimo, J. Raisanen, D. Mathews, J. Pascual, C. Madden, B. Mickey, C. Malloy, R. DeBerardinis, J. Mukherjee, S. Zheng, J. Phillips, C. Cowdrey, S. Ronen, J. Wiencke, R. O. Pieper, I. Park, L. E. Jalbert, M. Ito, T. Ozawa, C. D. James, J. J. Phillips, D. B. Vigneron, R. O. Pieper, S. M. Ronen, S. J. Nelson   +127 more
openaire   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

The MetaCyc Metabolic Pathway Database

, 2002
MetaCyc is a metabolic-pathway database (DB) that describes 445 pathways and 1115 enzymes occurring in 158 organisms. As a general reference source on metabolic pathways, MetaCyc serves several purposes in metabolic engineering.
Peter D. Karp
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Editorial: Perspectives in pharmacological therapy targeting cellular metabolic pathways in respiratory diseases

Frontiers in Pharmacology, 2023
Na Wang, Jie Liu, Peiran Yang, Dustin Fraidenburg, Haiyang Tang   +4 more
doaj   +1 more source

Polyurethane biodegradation by Fusarium parceramosum with insights into kinetic modelling and metabolic pathway. [PDF]

Bioresour Bioprocess
Sahu P, Sherigar A, Raval R, Lin C, Selvaraj S.   +4 more
europepmc   +1 more source

Pathways of Drug Metabolism,

Journal of Pharmacy and Pharmacology, 1956
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Inhibitors of the FASII Metabolic Pathway in <i>Toxoplasma gondii</i>: Advances and Therapeutic Perspectives. [PDF]

Microorganisms
Castillo-Villanueva CJ, Anacleto-Santos J, López-Pérez TJ, Casarrubias-Tabarez B, Fortoul TI, Rojas-Lemus M, López-Valdez N, Vega-Ávila E, Calzada F, López-Camacho PY, Rivera-Fernández N.   +10 more
europepmc   +1 more source