Results 81 to 90 of about 2,197,729 (354)

Low thyroxine serves as an upstream regulator of ecophysiological adaptations in Ansell’s mole-rats

Frontiers in Endocrinology
IntroductionAbout 10% of all rodent species have evolved a subterranean way of life, although life in subterranean burrows is associated with harsh environmental conditions that would be lethal to most animals living above ground. Two key adaptations for
Patricia Gerhardt, Sabine Begall, Caroline Frädrich, Kostja Renko, Alexandra Heinrich, Josef Köhrle, Yoshiyuki Henning   +6 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Energy conservation by collective movement in schooling fish

eLife
Many animals moving through fluids exhibit highly coordinated group movement that is thought to reduce the cost of locomotion. However, direct energetic measurements demonstrating the energy-saving benefits of fluid-mediated collective movements remain ...
Yangfan Zhang, George V Lauder
doaj   +1 more source

Predicting energy expenditures for activities of caribou from heart rates

Rangifer, 1986
Highly significant ...
Steve G. Fancy, Robert G. White
doaj   +1 more source

The energy savings-oxidative cost trade-off for migratory birds during endurance flight

eLife, 2020
Elite human and animal athletes must acquire the fuels necessary for extreme feats, but also contend with the oxidative damage associated with peak metabolic performance.
Scott McWilliams, Barbara Pierce, Andrea Wittenzellner, Lillie Langlois, Sophia Engel, John R Speakman, Olivia Fatica, Kristen DeMoranville, Wolfgang Goymann, Lisa Trost, Amadeusz Bryla, Maciej Dzialo, Edyta Sadowska, Ulf Bauchinger   +13 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Predation can shape the cascade interplay between heterothermy, exploration and maintenance metabolism under high food availability

Ecology and Evolution
Maintenance metabolism as the minimum energy expenditure needed to maintain homeothermy (a high and stable body temperature, Tb), reflects the magnitude of metabolic machinery and the associated costs of self‐maintenance in endotherms (organisms able to ...
Jan S. Boratyński, Karolina Iwińska, Martyna Wirowska, Zbigniew Borowski, Karol Zub   +4 more
doaj   +1 more source

Skeletal Muscle Oxidative Metabolism during Exercise Measured with Near Infrared Spectroscopy

NDT - Journal of Non-Destructive Testing
This study characterized the level of oxidative metabolism in skeletal muscle during whole-body activity as a percentage of the muscle’s maximum oxidative rate (mVO2max) using near-infrared spectroscopy (NIRS).
Kevin K. McCully, Sarah N. Stoddard, Mary Ann Reynolds, Terence E. Ryan   +3 more
doaj   +1 more source

Age-Related Changes in the Thermoregulatory Properties in Bank Voles From a Selection Experiment

Frontiers in Physiology, 2020
As with many physiological performance traits, the capacity of endotherms to thermoregulate declines with age. Aging compromises both the capacity to conserve or dissipate heat and the thermogenesis, which is fueled by aerobic metabolism.
Marta Grosiak, Paweł Koteja, Ulf Bauchinger, Ulf Bauchinger, Edyta T. Sadowska   +4 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source