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Metabolic control of antifungal drug resistance
Fungal Genetics and Biology, 2010Fungi have evolved an elegant repertoire of mechanisms to survive the cellular stress exerted by antifungal drugs such as azoles, which inhibit ergosterol biosynthesis inducing cell membrane stress. The evolution and maintenance of diverse resistance phenotypes is contingent upon cellular circuitry regulated by the molecular chaperone Hsp90 and its ...
Nicole, Robbins +3 more
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Essential hypertension, metabolic disorders, and insulin resistance
American Heart Journal, 1991Essential hypertension is frequently associated with several metabolic abnormalities, of which obesity, glucose intolerance, and dyslipidemia are the most common. This report discusses the epidemiologic evidence for the coexistence of these risk factors and questions why hyperinsulinemia and essential hypertension cosegregate.
FERRANNINI, ELEUTERIO, NATALI, ANDREA
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Metabolic Features of Cancer Treatment Resistance
2016A major barrier to achieving durable remission and a definitive cure in oncology patients is the emergence of tumor resistance, a common outcome of different disease types, and independent from the therapeutic approach undertaken. In recent years, subpopulations of slow-cycling cells endowed with enhanced tumorigenic potential and multidrug resistance ...
Andrea, Viale, Giulio F, Draetta
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Bacterial metabolism influences insulin resistance
Nature Reviews Microbiology, 2023openaire +2 more sources
Metabolic consequences of resistive-type exercise
Medicine & Science in Sports & Exercise, 1988This brief review concerns acute and chronic metabolic responses to resistive-type exercise (RTE) (i.e., Olympic/power weight lifting and bodybuilding). Performance of RTE presents power output substantially greater (10-15-fold) than that evident with endurance-type exercise. Accordingly, RTE relies heavily on the anaerobic enzyme machinery of skeletal
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Metabolic alterations drive enzalutamide resistance
Nature Reviews Urology, 2023openaire +2 more sources
Physiological limitations and opportunities in microbial metabolic engineering
Nature Reviews Microbiology, 2021José Montaño López, Jose L Avalos
exaly
Metabolic regulation of epigenetic drug resistance
Nature Chemical Biology, 2023Nathaniel W. Snyder, Jordan L. Meier
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Therapeutic RNA-silencing oligonucleotides in metabolic diseases
Nature Reviews Drug Discovery, 2022Markus Stoffel
exaly