Results 61 to 70 of about 875,811 (262)

Comparison of body mass index and physical activity levels of e-sportsmen

Frontiers in Public Health
BackgroundThis study examines the relationship between body mass index (BMI) and physical activity levels in e-sports players. Focusing on the sedentary lifestyle and health risks associated with prolonged sitting and low physical activity, the study ...
Burhan Başoğlu
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Metabolic syndrome and its correlates: A cross-sectional study among adults aged 18–49 years in an Urban Area of West Bengal

Indian Journal of Public Health, 2020
Background: The prevalence of metabolic syndrome (MetS) is increasing dramatically of late, across all ages irrespective of gender, socioeconomic status, and ethnicity.
Aparajita Dasgupta, Rajarshi Banerjee, Tania Pan, Sweta Suman, Utsa Basu, Bobby Paul   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Longitudinal assessment of metabolic and neurological decline in peripheral polyneuropathy over ten years

Future Science OA
Aims This research aims to evaluate changes in metabolic status and the development of peripheral polyneuropathy (PN) in Kazakhstan.Methods This longitudinal observational study followed a cohort of adults with metabolic syndrome, comparing clinical ...
Dinara Azizkhojayeva, Gulnaz Nuskabayeva, Karlygash Sadykova, Ainur Turmanbayeva, Dana Kaldarkhan, Nurlybek Mombekov, Nigara Yerkhojayeva, Malika Raimova, Umida Yodgarova, Saodat Sobirova, Kamshat Madenbay, Ainash Oshibayeva   +11 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Rising clustering of metabolic risk factors and behavioral-metabolic profiles in Viet Nam, 2015–2021: repeated cross-sectional surveys

International Journal of Public Health
ObjectivesEvidence on the burden and clustering of metabolic non-communicable disease risks and on data-driven risk profiles remains limited. This study assessed trends in the clustering of metabolic risk factors in Viet Nam from 2015 to 2021 and ...
Duy Quang Pham, Thi Tu Quyen Bui, Hung Minh Nguyen, Minh Van Hoang   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Association between metabolic obesity phenotypes and the risk of developing prostate cancer: a propensity score matching study based on Xinjiang

Frontiers in Endocrinology
BackgroundObesity-induced metabolic dysfunction increases the risk of developing tumors, however, the relationship between metabolic obesity phenotypes and prostate cancer (PCa) remains unclear.MethodsThe term metabolic obesity phenotypes was introduced ...
Jinru Wang, Aireti Apizi, Hao Qiu, Ning Tao, Hengqing An   +4 more
doaj   +1 more source