Results 81 to 90 of about 875,811 (262)

Comparing Adolescents at Risk and Not at Risk of Non-Communicable Disease in Terms of Body Composition and Physical Activity in the Eastern Cape, South Africa

Physical Activity and Health
Non-communicable diseases (NCDs) accounted for 51% of total deaths in South Africa in 2016. Adolescents demonstrating unfavorable body composition and low levels of physical activity are more susceptible to additional risk factors associated with NCDs ...
Sisanda Mvula, Maya Maria Van Gent, Rudolph Leon van Niekerk   +2 more
doaj   +1 more source

Strong association between metabolically-abnormal obesity and gallstone disease in adults under 50 years

BMC Gastroenterology, 2019
Background Age, obesity, and metabolic syndrome are known risk factors for gallstones; however, the combined impact of these different risk factors on gallstone formation has not yet been examined.
Pei-yuan Su, Yu-Chun Hsu, Yu-fang Cheng, Chew-Teng Kor, Wei-Wen Su   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Health determinants among participants in targeted health dialogues offered to all 40-year-old individuals in a metropolitan region of 1.4 million people

Scandinavian Journal of Primary Health Care
Objective To examine cardiovascular risk factors in 40-year-old participants in the health screening program targeted health dialogues (THDs).Design Cross-sectional study.Setting 99 Swedish healthcare centers.Intervention Metabolic risk factors and ...
Emelie Stenman, Beata Borgström Bolmsjö, Anton Grundberg, Kristina Sundquist   +3 more
doaj   +1 more source

Metabolic syndrome as a risk factor for gallstone disease

World Journal of Gastroenterology, 2005
To establish an association between the presence of metabolic syndrome and the development of gallstone disease.We carried out a cross-sectional study in a check-up unit in a university hospital in Mexico City. We enrolled 245 subjects, comprising 65 subjects with gallstones (36 women, 29 men) and 180 controls (79 women and 101 men without gallstones).
Nahum, Méndez-Sánchez, Norberto C, Chavez-Tapia, Daniel, Motola-Kuba, Karla, Sanchez-Lara, Guadalupe, Ponciano-Rodríguez, Héctor, Baptista, Martha H, Ramos, Misael, Uribe   +7 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Cardiovascular-kidney-metabolic syndrome — a new concept of the association of risk factors and metabolic disorders within the cardiovascular and renal continuum. View on the issue

Российский кардиологический журнал
In 2023, the American Heart Association for the first time formally defined cardiovascular-kidney-metabolic (CKM) syndrome as a systemic disease characterized by pathophysiological interactions between metabolic risk factors, chronic kidney disease (CKD),
G. G. Arabidze, M. N. Mamedov
doaj   +1 more source

Metabolic Syndrome: A Multiplex Cardiovascular Risk Factor [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2007
The metabolic syndrome (MetS) is a multiplex risk factor for cardiovascular disease. The syndrome develops through interplay of obesity and metabolic susceptibility.This article addresses whether the MetS construct has clinical utility. POSITION: The National Cholesterol Education Program and other organizations have proposed that the MetS can be ...
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Risks of Metabolic Syndrome in Students of the Faculty of Health Sciences

Balkan Medical Journal, 2013
Background: Metabolic syndrome is highly prevalent in the adult population worldwide. Education may play an important role in preventing metabolic syndrome in young adults, especially those who are attending university.
Ersin Öğüş, Mustafa Agah Tekindal, Yelda Ceylan, Merve Demirel, Neşe Emecioğlu, İlçim Ercan, Deniz Eroğlu, Sevinç Haner   +7 more
doaj   +1 more source