Results 131 to 140 of about 460,394 (253)

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Analysis of metabolic stability under environmental perturbations using a kinetic model. [PDF]

Biophys Physicobiol
Hishida A, Himeoka Y, Furusawa C.
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Engineering an Artificial Myxopyronin Derivative with Enhanced Metabolic Stability via Mutasynthesis. [PDF]

JACS Au
Kiefer AF, Voltz A, Scherzer D, Reberšek R, Kany AM, Prosser G, Neuber M, Reiling N, Hirsch AKH, Müller R.   +9 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain of <i>Mycobacterium tuberculosis</i> Displaying Enhanced Metabolic Stability. [PDF]

J Med Chem
Mosallam N, O'Neill PM, Lisauskaitė M, Woodley CM, Ardrey A, Jeffreys LN, Memelis I, Almeida D, Lee J, Converse PJ, Cantillon D, Nuermberger EL, Bald D, Biagini GA, Hong WD, Berry NG, Nixon GL.   +16 more
europepmc   +1 more source

CMMS-GCL: cross-modality metabolic stability prediction with graph contrastive learning. [PDF]

Bioinformatics, 2023
Du BX, Long Y, Li X, Wu M, Shi JY.
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Controlling metabolic stability of food microbiome for stable indigenous liquor fermentation. [PDF]

NPJ Biofilms Microbiomes
Tan Y, Zhu Y, Wijffels RH, Zhang H, Scott WT, Xu Y, Martins Dos Santos V.   +6 more
europepmc   +1 more source

Metabolic stability and metabolite profiling of emerging synthetic cathinones. [PDF]

Front Pharmacol, 2023
Lopes RP, Ferro RA, Milhazes M, Figueira M, Caldeira MJ, Antunes AMM, Gaspar H.   +6 more
europepmc   +1 more source