Results 11 to 20 of about 425,696 (264)
Biological Activity and Stability of Aeruginosamides from Cyanobacteria
Marine Drugs, 2022 Aeruginosamides (AEGs) are classified as cyanobactins, ribosomally synthesized peptides with post-translational modifications. They have been identified in cyanobacteria of genera Microcystis, Oscillatoria, and Limnoraphis.
Marta Cegłowska +7 more
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On the stability of metabolic cycles [PDF]
Journal of Theoretical Biology, 2010 We investigate the stability properties of two different classes of metabolic cycles using a combination of analytical and computational methods. Using principles from structural kinetic modeling (SKM), we show that the stability of metabolic networks with certain structural regularities can be studied using a combination of analytical and ...
Reznik, Ed, Segrè, Daniel
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The Metabolic Stability of the Nicotinic Acetylcholine Receptor at the Neuromuscular Junction
Cells, 2021 The clustering and maintenance of nicotinic acetylcholine receptors (AChRs) at high density in the postsynaptic membrane is a hallmark of the mammalian neuromuscular junction (NMJ).
Isabel Martinez-Pena y Valenzuela +1 more
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Viruses, 2021 Small molecules targeting the PF74 binding site of the HIV-1 capsid protein (CA) confer potent and mechanistically unique antiviral activities. Structural modifications of PF74 could further the understanding of ligand binding modes, diversify ligand ...
Rajkumar Lalji Sahani +12 more
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Pharmaceutical Biology, 2020 Context Ligustrazine and valsartan are commonly used drugs in the treatment of cardiac and cardiovascular disease. Objective The interaction between ligustrazine and valsartan was studied to investigate the effect of ligustrazine on the pharmacokinetics ...
Yang Liu, Jiaqi Zhang, Di Wu, Liran Cui
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Methods to Enhance the Metabolic Stability of Peptide-Based PET Radiopharmaceuticals
Molecules, 2020 The high affinity and specificity of peptides towards biological targets, in addition to their favorable pharmacological properties, has encouraged the development of many peptide-based pharmaceuticals, including peptide-based positron emission ...
Brendan J. Evans +4 more
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In vitro and in vivo pharmacokinetic characterization of LMT-28 as a novel small molecular interleukin-6 inhibitor [PDF]
Asian-Australasian Journal of Animal Sciences, 2020 Objective Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, in vitro liver microsomal ...
Sung-Hoon Ahn +3 more
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Metabolically stabilized double-stranded mRNA polyplexes [PDF]
Gene Therapy, 2018 The metabolic instability of mRNA currently limits its utility for gene therapy. Compared to plasmid DNA, mRNA is significantly more susceptible to digestion by RNase in the circulation following systemic dosing. To increase mRNA metabolic stability, we hybridized a complementary reverse mRNA with forward mRNA to generate double-stranded mRNA (dsmRNA).
Jacob A, Poliskey +5 more
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Metabolic Stability of New Mito-Protective Short-Chain Naphthoquinones
Pharmaceuticals, 2020 Short-chain quinones (SCQs) have been identified as potential drug candidates against mitochondrial dysfunction, which is largely dependent on their reversible redox characteristics of the active quinone core. We recently synthesized a SCQ library of >
Zikai Feng +3 more
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Global Stability of Reversible Enzymatic Metabolic Chains [PDF]
Acta Biotheoretica, 2013 We consider metabolic networks with reversible enzymatic reactions. The model is written as a system of ordinary differential equations, possibly with inputs and outputs. We prove the global stability of the equilibrium (if it exists), using techniques of monotone systems and compartmental matrices.
Ndiaye, Ibrahima, Gouzé, Jean-Luc
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