Results 11 to 20 of about 460,394 (253)
CYP2C9 mediates the herb-drug interaction of curcumin with naproxen in rats [PDF]
Acta Poloniae Pharmaceutica, 2023 Both curcumin and naproxen possess the activity of pain relief, which makes it possible to co-administrate these drugs in the same prescription. This study aimed to assess the potential pharmacokinetic interaction of naproxen with curcumin in rats ...
Yongjun Qiu, Sujun Huang, Minfang Zhu
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Frontiers in Pharmacology, 2023 Eupalinolide A (EA; Z-configuration) and eupalinolide B (EB; E-configuration) are bioactive cis-trans isomers isolated from Eupatorii Lindleyani Herba that exert anti-inflammatory and antitumor effects.
Yingzi Li +8 more
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Pharmaceutics, 2023 Alectinib, also known as Alecensa®, is prescribed for the therapeutic treatment of individuals diagnosed with metastatic non-small cell lung cancer (NSCLC) who have a specific genetic mutation referred to as anaplastic lymphoma kinase (ALK) positivity ...
Mohamed W. Attwa +3 more
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Molecules, 2022 The purpose of this study was to identify potential metabolic pathways and metabolites of OJT007, a methionine aminopeptidase 1 (MetAP1) inhibitor. OJT007 is a novel drug with potent antiproliferative effects against Leishmania Major.
Maria Eugenia Rincon Nigro +6 more
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On the stability of metabolic cycles [PDF]
Journal of Theoretical Biology, 2010 We investigate the stability properties of two different classes of metabolic cycles using a combination of analytical and computational methods. Using principles from structural kinetic modeling (SKM), we show that the stability of metabolic networks with certain structural regularities can be studied using a combination of analytical and ...
Reznik, Ed, Segrè, Daniel
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Molecules, 2023 Selpercatinib (SLP; brand name Retevmo®) is a selective and potent RE arranged during transfection (RET) inhibitor. On 21 September 2022, the FDA granted regular approval to SLP (Retevmo, Eli Lilly, and Company).
Mohamed W. Attwa +4 more
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Biological Activity and Stability of Aeruginosamides from Cyanobacteria
Marine Drugs, 2022 Aeruginosamides (AEGs) are classified as cyanobactins, ribosomally synthesized peptides with post-translational modifications. They have been identified in cyanobacteria of genera Microcystis, Oscillatoria, and Limnoraphis.
Marta Cegłowska +7 more
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Viruses, 2021 Small molecules targeting the PF74 binding site of the HIV-1 capsid protein (CA) confer potent and mechanistically unique antiviral activities. Structural modifications of PF74 could further the understanding of ligand binding modes, diversify ligand ...
Rajkumar Lalji Sahani +12 more
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THE EXCRETION AND STABILITY TO METABOLISM OF BRETYLIUM [PDF]
British Journal of Pharmacology and Chemotherapy, 1960 Bretylium (o‐bromobenzylethyldimethylammonium) is a new type of hypotensive drug. It was estimated in extracts of human urine as the methyl orange complex. From 7 to 45% of a single oral dose was found in human urine within 9 hr. The [14C] labelled drug was used to investigate excretion by cats.
W G, DUNCOMBE, A, McCOUBREY
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Pharmaceutical Biology, 2020 Context Ligustrazine and valsartan are commonly used drugs in the treatment of cardiac and cardiovascular disease. Objective The interaction between ligustrazine and valsartan was studied to investigate the effect of ligustrazine on the pharmacokinetics ...
Yang Liu, Jiaqi Zhang, Di Wu, Liran Cui
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