Results 61 to 70 of about 425,696 (264)

Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis

Medicina, 2021
Background and Objectives: The present study demonstrates that apart from the well-known toxicity of liposoluble vitamins, some hydrosoluble vitamins may also exert toxicity; thus, routine supplementation with vitamins or ingestion of fortified foods ...
Mirela Nicolov, Mioara Cocora, Valentina Buda, Corina Danciu, Adina Octavia Duse, Claudia Watz, Florin Borcan   +6 more
doaj   +1 more source

Stability of Metabolic and Balanced Organisations [PDF]

, 2001
We investigate the possible organisations emerging from an artificial chemistry (AC) of colliding molecules in a well stirred reactor. The molecules are generated from 7 basic components (atoms), each with a different behavior. After discovering two main types of organisations (metabolic o.
Pietro Speroni di Fenizio, Wolfgang Banzhaf   +1 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Approximating the stabilization of cellular metabolism by compartmentalization [PDF]

Theory in Biosciences, 2016
Biochemical regulation in compartmentalized metabolic networks is highly complex and non-intuitive. This is particularly true for cells of higher plants showing one of the most compartmentalized cellular structures across all kingdoms of life. The interpretation and testable hypothesis generation from experimental data on such complex systems is a ...
Fürtauer, Lisa, Nägele, Thomas
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

In Vitro Structure–Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases

Pharmacology Research & Perspectives
The primary degradation pathway for antisense oligonucleotides (ASOs) involves endonuclease and exonuclease‐mediated breakdown. The effect of various chemical modifications on the stability of oligonucleotides has not been systematically investigated ...
Jelena Lovrić, Jingjing Yan, XueQing Li, Tony Karlsborn, Mattias Bood, Anders Dahlén, Constanze Hilgendorf, Deepak Kumar Bhatt   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Metabolic stability of the fucose in rat transferrin [PDF]

FEBS Letters, 1987
The metabolic behaviour of the chitobiose core fucose that is a natural constituent of a large proportion of rat transferrin molecules was studied in rats comparatively to that of the polypeptide portion of the glyco‐protein by using appropriate labels ([3H]fucose and 125I) and affinity chromatographic techniques (lentil‐Sepharose).
Regoeczi, Erwin, Chindemi, Paul A.
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Stability of Several Biochemical Markers of Bone Metabolism [PDF]

Clinical Chemistry, 2000
The determination of bone metabolism markers is useful in monitoring pharmacological therapy for osteoporosis (1)(2)(3). During the course of multicenter clinical studies designed to evaluate the therapeutic efficacy of several drugs, it often is useful to carry out analysis in batches after storing the samples for differing periods, thus reducing ...
A, Lomeo, A, Bolner
openaire   +2 more sources