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Metabolic Syndrome: Updates on Pathophysiology and Management in 2021

International Journal of Molecular Sciences, 2022
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin resistance, atherogenic dyslipidemia, central obesity, and hypertension.
Gracia Fahed, Lawrence Aoun, Morgan Bou Zerdan, Sabine Allam, M. Bou Zerdan, Y. Bouferraa, H. Assi   +6 more
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Targeting transforming growth factor beta (TGF-β) using Pirfenidone, a potential repurposing therapeutic strategy in colorectal cancer

Scientific Reports, 2023
The modulating factors within the tumor microenvironment, for example, transforming growth factor beta (TGF-β), may limit the response to chemo and immunotherapy protocols in colorectal cancer (CRC).
Hamid Jamialahmadi, Seyedeh Elnaz Nazari, Hamid TanzadehPanah, Ehsan Saburi, Fereshteh Asgharzadeh, Fatemeh Khojasteh-Leylakoohi, Maryam Alaei, Mahdi Mirahmadi, Fatemeh Babaei, Seyedeh Zahra Asghari, Saeide Mansouri, Ghazaleh Khalili-Tanha, Mina Maftooh, Hamid Fiuji, Seyed Mahdi Hassanian, Gordon A. Ferns, Majid Khazaei, Amir Avan   +17 more
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Mechanisms of Oxidative Stress in Metabolic Syndrome

International Journal of Molecular Sciences, 2023
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which
S. Masenga, Lombe S. Kabwe, Martin Chakulya, Annet Kirabo   +3 more
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Machine learning algorithms reveal potential miRNAs biomarkers in gastric cancer

Scientific Reports, 2023
Gastric cancer is the high mortality rate cancers globally, and the current survival rate is 30% even with the use of combination therapies. Recently, mounting evidence indicates the potential role of miRNAs in the diagnosis and assessing the prognosis ...
Hanieh Azari, Elham Nazari, Reza Mohit, Alireza Asadnia, Mina Maftooh, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Soodabeh Shahidsales, Majid Khazaei, Gordon A. Ferns, Amir Avan   +11 more
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Down regulation of Cathepsin W is associated with poor prognosis in pancreatic cancer

Scientific Reports, 2023
Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis. Therefore, there has been a focus on identifying new biomarkers for its early diagnosis and the prediction of patient survival.
Fatemeh Khojasteh-Leylakoohi, Reza Mohit, Nima Khalili-Tanha, Alireza Asadnia, Hamid Naderi, Ghazaleh Pourali, Zahra Yousefli, Ghazaleh Khalili-Tanha, Majid Khazaei, Mina Maftooh, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon A. Ferns, Soodabeh Shahidsales, Alfred King-yin Lam, Elisa Giovannetti, Elham Nazari, Jyotsna Batra, Amir Avan   +19 more
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Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model

Pharmaceuticals, 2023
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial.
Seyedeh Elnaz Nazari, Alex Tarnava, Nima Khalili-Tanha, Mahdieh Darroudi, Ghazaleh Khalili-Tanha, Amir Avan, Majid Khazaei, Tyler W. LeBaron   +7 more
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Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

Current Opinion in Cardiology, 2005
The metabolic syndrome has received increased attention in the past few years. This statement from the American Heart Association (AHA) and the National Heart, Lung, and Blood Institute (NHLBI) is intended to provide up-to-date guidance for professionals
S. Grundy, J. Cleeman, S. Daniels, K. Donato, R. Eckel, B. Franklin, D. Gordon, R. Krauss, P. Savage, Sidney C. Smith, J. Spertus, F. Costa   +11 more
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Diagnostic Value of CK19, HBME-1 and TROP2 Biomarkers in Identification of Different Types of Thyroid Follicular Neoplasms

Acta Medica Iranica, 2021
Thyroid malignancies are found in 7% to 15% of all thyroid nodules. Immunohistochemical markers, including CK19, HBME-1and TROP2, have shown an effective role in identifying these malignancies.
Masoud Mohebbi, Shohreh Vojuhi, Zohreh Mousavi, Mohammadali Yaghoubi, Reza Ziaolhagh   +4 more
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A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association

Circulation, 2023
A growing appreciation of the pathophysiological interrelatedness of metabolic risk factors such as obesity and diabetes, chronic kidney disease, and cardiovascular disease has led to the conceptualization of cardiovascular-kidney-metabolic syndrome. The
C. Ndumele, I. Neeland, Katherine Tuttle, Sheryl L Chow, Roy O Mathew, Sadiya S. Khan, J. Coresh, C. Baker-Smith, M. Carnethon, Jean-Pierre Després, Jennifer E Ho, Joshua J Joseph, Walter N Kernan, Amit Khera, Mikhail N. Kosiborod, Carolyn L. Lekavich, Eldrin F. Lewis, Kevin B Lo, Bige Ozkan, Latha P. Palaniappan, Sonali S Patel, Michael J. Pencina, Tiffany Powell-wiley, Laurence S Sperling, Salim S. Virani, Jackson T Wright, Radhika Rajgopal Singh, Mitchell S. V. Elkind, J. Rangaswami   +28 more
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Metabolic Syndrome in Children and Adolescents

Ewha Medical Journal, 2022
Background: Metabolic syndrome is a serious condition associated with multiple diseases. The prevalence of metabolic syndrome is increasing caused by an increase in obesity rates among children and adolescents.Current Concepts: Owing to the various ...
Yoojin Lindsey Chung, Y. Rhie
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