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Cardiac syndrome X versus metabolic syndrome X
International Journal of Cardiology, 2007In 1973, Kemp [1], in an editorial, introduced the term ‘syndrome X’ to indicate the uncertain etiology of chest pain in patients who had a positive exercise ECG suggestive of myocardial ischemia but on coronary arteriograms had normal coronary arteries.
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Thymidylate metabolism in fragile X syndrome cells
Somatic Cell and Molecular Genetics, 1985The observation that decreased thymidylate supply in vitro induces the expression of the Xq27 chromosome fragile site prompted us to examine cellular thymidylate metabolism. Using a sensitive enzyme assay for deoxyribonucleotide triphosphates, we found that the total cellular thymidine triphosphate pools in cell lines from fragile X patients and ...
J C, Wang, R W, Erbe
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Cyclic AMP metabolism in fragile X syndrome
Annals of Neurology, 1992AbstractCyclic AMP (cAMP) metabolism was studied in platelets from a series of 14 patients with fragile X syndrome (fra X) and 21 control individuals. 1‐Isobutyl‐3‐methylxanthine was used to inhibit phosphodiesterase and thus measure cAMP production, prostaglandin E1 was used to assess receptor‐mediated cAMP accumulation, and forskolin was used to ...
E, Berry-Kravis, P R, Huttenlocher
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The Metabolic Syndrome X And Peripheral Cortisol Synthesis
Experimental and Clinical Endocrinology & Diabetes, 2002The metabolic syndrome X and Cushing's syndrome show similar symptoms but one major difference: Plasma cortisol is not elevated in the metabolic syndrome. Evidence is presented, that by the action of 11 beta-hydroxysteroid dehydrogenase 1 (11 beta HSD1) higher intracellular cortisol concentration may be created that may be relevant to induce insulin ...
V, Bähr, A F, Pfeiffer, S, Diederich
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Metabolic syndrome X: An inflammatory condition?
Current Hypertension Reports, 2004Obesity, atherosclerosis, insulin resistance and hyperinsulinemia, hyperlipidemia, essential hypertension, type 2 diabetes mellitus, and coronary heart disease (CHD) are the components of metabolic syndrome X and are associated with elevated plasma levels of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha, which are markers of ...
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The Nurse Practitioner, 1996
Recent trends in the American lifestyle, such as a high-fat diet and inactivity, have promoted the emergence of a metabolic disorder titled syndrome X. Although originally linked to non-insulin-dependent diabetes mellitus (NIDDM) and characterized by insulin resistance, syndrome X is now better described as a cascade of disorders encompassing not only ...
L E, Minchoff, J A, Grandin
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Recent trends in the American lifestyle, such as a high-fat diet and inactivity, have promoted the emergence of a metabolic disorder titled syndrome X. Although originally linked to non-insulin-dependent diabetes mellitus (NIDDM) and characterized by insulin resistance, syndrome X is now better described as a cascade of disorders encompassing not only ...
L E, Minchoff, J A, Grandin
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Low-flow vascular remodeling in the metabolic syndrome X
American Journal of Physiology-Heart and Circulatory Physiology, 2004Peripheral microvascular dysfunction is a common affliction in patients with the metabolic syndrome X. Previous studies have described a number of vascular impairments in vasomotor control in both human patients and animal models of syndrome X, but the net effect of these impairments on microvascular structure has not been examined.
David W, Stepp +2 more
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Folate metabolism and chromosomal stability in the fragile X syndrome
The American Journal of Medicine, 1984Folate metabolism and the effects of folic acid on chromosome stability were studied in four related patients with the fragile X syndrome. In three adults, uptake and subsequent utilization of folate compounds for conversion of deoxyuridylate to thymidylate by marrow cells and stimulated lymphocytes, and the affinity and maximal transport velocity of ...
R F, Branda +4 more
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Metabolic syndrome X: a review.
The Canadian journal of cardiology, 2000Metabolic syndrome X is a multifaceted syndrome, which occurs frequently in the general population. It is more common in men than in women. A large segment of the adult population of industrialized countries develops the metabolic syndrome, produced by genetic, hormonal and lifestyle factors such as obesity, physical inactivity and certain nutrient ...
O, Timar, F, Sestier, E, Levy
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Molecular mechanism of vascular disease in metabolic syndrome X
Journal of Diabetes and its Complications, 2002Syndrome X is a clinical syndrome in which multiple risks are clustered in an individual and is a common basis of vascular disease in the industrial countries. However, the molecular basis of syndrome X has not been elucidated. We have analyzed body fat distribution using CT scanning and have shown that accumulated intra-abdominal visceral fat is ...
Yuji, Matsuzawa +2 more
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