Results 161 to 170 of about 198,582 (348)
Genotype networks, innovation, and robustness in sulfur metabolism [PDF]
arXiv, 2010 Metabolic networks are complex systems that comprise hundreds of chemical reactions which synthesize biomass molecules from chemicals in an organism's environment. The metabolic network of any one organism is encoded by a metabolic genotype, defined by a set of enzyme-coding genes whose products catalyze the network's reactions. Each metabolic genotype
arxiv
Iduronate-2-sulfatase interactome: validation by yeast two-hybrid assay
Heliyon, 2022 Background: Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a rare X-linked recessive disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS), which activates intracellular accumulation of ...
Eliana Benincore-Flórez +6 more
doaj
The untapped power of a general theory of organismal metabolism [PDF]
arXivWhat makes living things special is how they manage matter, energy, and entropy. A general theory of organismal metabolism should therefore be quantified in these three currencies while capturing the unique way they flow between individuals and their environments. We argue that such a theory has quietly arrived -- 'Dynamic Energy Budget' (DEB) theory --
arxiv
Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry
Mass Spectrometry Reviews, EarlyView.ABSTRACT Mass spectrometry (MS) is a powerful analytical technique that typically involves sample preparation and online analytical separation before MS detection. Traditional methods often face bottlenecks in sample preparation and analytical separation, despite the rapid detection capabilities of MS.
Nicholas E. Manicke +2 more
wiley +1 more source
Antithrombin: Deficiency, Diversity, and the Future of Diagnostics
Mass Spectrometry Reviews, EarlyView.ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt +2 more
wiley +1 more source
The Turkish Journal of Pediatrics, 2019 Guanidinoacetate methyltransferase (GAMT) deficiency is a rare autosomal recessive disorder of creatine biosynthesis. Here, we report 9 and 10-year-old cousins with GAMT deficiency caused by a novel mutation who both exhibited neurodevelopmental ...
Halil İbrahim Aydın +1 more
doaj +1 more source
Critical dynamics of gene networks is a mechanism behind ageing and Gompertz law [PDF]
arXiv, 2015 Although accumulation of molecular damage is suggested to be an important molecular mechanism of aging, a quantitative link between the dynamics of damage accumulation and mortality of species has so far remained elusive. To address this question, we examine stability properties of a generic gene regulatory network (GRN) and demonstrate that many ...
arxiv
Scientific Reports, 2019 Inherited metabolic disorders (IMDs) in neonates are a diagnostic and therapeutic challenge for the neonatologist, with the priority being to rapidly flag the treatable diseases.
Alexandra Bower +6 more
doaj +1 more source
Topological Quantum Computation and Error Correction by Biological Cells [PDF]
arXiv, 2005 A Topological examination of phospholipid dynamics in the Far from Equilibrium state has demonstrated that metabolically active cells use waste heat to generate spatially patterned membrane flows by forced convection and shear. This paper explains the resemblance between this nonlinear membrane model and Witten Kitaev type Topological Quantum ...
arxiv
The role of exome sequencing in newborn screening for inborn errors of metabolism
Nature Network Boston, 2020 Aashish N. Adhikari +23 more
semanticscholar +1 more source