Results 171 to 180 of about 198,582 (348)
Sex‐specific white matter alterations in children exposed to high pregestational BMI
Obesity, EarlyView.Abstract Objective This study investigated whether exposure to high pregestational BMI (≥ 25 kg/m2) is associated with alterations in white matter microstructure in early childhood, explored sex‐specific effects, and examined associations with cognitive performance. Methods A total of 90 children from the Alberta Pregnancy Outcomes and Nutrition (APrON)
Samson Nivins +5 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Hematopoietic stem cell transplantation (HCT) is a potentially curative treatment for children with hematological or immunological disorders. However, treatment‐related morbidity and mortality remain concerning. Various comorbidity indices are currently used to assess the risk of complications following pediatric HCT.
Roos Lotte Alexandra Bukman +4 more
wiley +1 more source
Neuroimaging in inborn errors of metabolism [PDF]
Nasljedne metaboličke bolesti pripadaju skupini od više od 8.000 monogenski nasljednih bolesti, a prema online bazi podataka o nasljednim metaboličkim bolestima (IEMbase), do sada ih je poznato oko 1.900.
Hrkać Pustahija, Ana, Ozretić, David
core +2 more sources
PET Quantification of Ultra Low Activity via Inhomogeneous Poisson Process Parameters Estimation Directly from Listmode Data [PDF]
arXiv, 2019 Metabolic imaging with PET/CT using $^{18}$F-Fludeoxyglucose ($^{18}$F-FDG) as well as other imaging biomarkers has achieved wide acceptance in oncology, cardiology and neurology not only because of the unique metabolic information generated by this modality, but also because of its ability to quantify biological processes.
arxiv
Prenatal Diagnosis, EarlyView.ABSTRACT This manuscript summarises the debate held at the 2024 annual meeting of The International Society for Prenatal Diagnosis (ISPD). Experts discussed whether all fetuses undergoing fetal therapy should undergo exome sequencing. Arguments in favor included that, with increasing experience and better clinical availability, exome sequencing can ...
Teresa N. Sparks +2 more
wiley +1 more source
Enzyme economy and metabolic control [PDF]
arXiv, 2014 The metabolic state of a cell, comprising fluxes, metabolite concentrations and enzyme levels, is shaped by a compromise between metabolic benefit and enzyme cost. This hypothesis and its consequences can be studied by computational models and using a theory of metabolic value.
arxiv
Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings
Pediatric Discovery, EarlyView.Abstract Spina bifida is a birth defect resulting from abnormal embryonic development of the neural tube. Though spina bifida is divided into several subtypes, myelomeningocele—the most severe form of spina bifida often associated with a markedly diminished quality of life—accounts for a significant portion of cases.
Ethan S. Wong +13 more
wiley +1 more source
Diagnosis and treatment of progressive multiple sclerosis: A position paper
European Journal of Neurology, Volume 30, Issue 1, Page 9-21, January 2023., 2023 Abstract Background and Purpose Multiple sclerosis (MS) is an unpredictable disease characterised by a highly variable disease onset and clinical course. Three main clinical phenotypes have been described. However, distinguishing between the two progressive forms of MS can be challenging for clinicians.
Carlo Pozzilli +6 more
wiley +1 more source
Dissociation of AGAT, GAMT and SLC6A8 in CNS: Relevance to creatine deficiency syndromes
Neurobiology of Disease, 2010 AGAT and GAMT, the two enzymes of the creatine synthesis pathway, are well expressed within CNS, suggesting autonomous brain creatine synthesis. This contradicts SLC6A8 deficiency, which causes creatine deficiency despite CNS expression of AGAT and GAMT.
Olivier Braissant +3 more
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