Results 211 to 220 of about 5,570,553 (408)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Comprehensive transcriptome and metabolome analysis to exploration the effects of TCs on GCs lipid metabolism at goose pre-ovulatory follicle. [PDF]

PLoS One
Ma J, Sun W, Yuan X, Long H, Shen H, Liu C, Gan X.   +6 more
europepmc   +1 more source

Bifidobacterium breve with α-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome

, 2012
Eoin Barrett, Patrick Fitzgerald, Timothy G. Dinan, John F. Cryan, R. Paul Ross, Eamonn M.M. Quigley, Fergus Shanahan, Barry Kiely, Gerald F. Fitzgerald, Paul W. O’Toole, Catherine Stanton   +10 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Comparative Metabolomic Approaches to Nanoplastic Toxicity in Mammalian and Aquatic Systems. [PDF]

Int J Mol Sci
Lee J, Jang H, Kim B, Jung J.
europepmc   +1 more source

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.

Cell Host and Microbe, 2018
A. Agus, J. Planchais, H. Sokol
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Advances in the Regulatory Mechanism of Enzymes Involved in Soluble Sugar Metabolism in Fruits. [PDF]

Plants (Basel)
Meng Z, Li W, Huang G, Li X, Li R, Chen Y, Luo S, Guo L, Tang Y, Tang Y, Zhang Y, Ma X, Li L.   +12 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics. [PDF]

Brain Behav
Chen ZC, Xu FB, Hu S, Cui Q, Barazarte HA, Zhang J, Suo LN, Gu JJ, Xue JY.   +8 more
europepmc   +1 more source