Results 281 to 290 of about 5,570,553 (408)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The value of lipid metabolism-related genes in pancreatic cancer immunotherapy and drug prediction. [PDF]

J Gastrointest Oncol
Xue R, Tao Z, Bai R, Shao Y, Liu N, Wang C.   +5 more
europepmc   +1 more source

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Nature reviews. Drug discovery, 2019
M. Plattén, E. Nollen, U. Röhrig, F. Fallarino, C. Opitz   +4 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The emerging role of cholesterol metabolism in gynecologic cancer development and therapy. [PDF]

Apoptosis
Liu H, Zhou Y, Zhang J, Miao L, Wu Q, Zhu H, Pan S, Zhu X.   +7 more
europepmc   +1 more source

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Science, 2013
V. Ridaura, J. Faith, F. Rey, Jiye Cheng, A. Duncan, A. Kau, Nicholas W. Griffin, V. Lombard, B. Henrissat, J. Bain, M. Muehlbauer, O. Ilkayeva, C. Semenkovich, K. Funai, David K. Hayashi, B. Lyle, M. Martini, L. Ursell, J. Clemente, William W. Van Treuren, W. Walters, R. Knight, C. Newgard, A. Heath, J. Gordon   +24 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

CES3 promotes NSCLC progression via lipid metabolic reprogramming regulated by TFAP2A. [PDF]

J Cancer
Luo P, Huang Z, Ding S, Tang Z, Wei Y, Jiang S, Tang R, Li F, Yang H, Zhao L.   +9 more
europepmc   +1 more source

Folate metabolism – epigenetic role of choline and vitamin B12 during pregnancy

, 2015
Krzysztof Drews
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source