Results 101 to 110 of about 527,693 (324)

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

DWARF27 and CAROTENOID CLEAVAGE DIOXYGENASE 7 genes regulate release, germination and growth of gemma in Marchantia polymorpha

Frontiers in Plant Science
Strigolactones (SLs), a class of carotenoid-derived hormones, play a crucial role in flowering plants by regulating underground communication with symbiotic arbuscular mycorrhizal fungi (AM) and controlling shoot and root architecture.
Rubina Jibran, Jibran Tahir, Christelle M. Andre, Bart J. Janssen, Revel S. M. Drummond, Nick W. Albert, Yanfei Zhou, Kevin M. Davies, Kimberley C. Snowden   +8 more
doaj   +1 more source

Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron, Remika Mito, Samuel F. Berkovic, Graeme D. Jackson   +3 more
wiley   +1 more source

Using statistical techniques and replication samples for imputation of metabolite missing values [PDF]

arXiv, 2019
Background: Data preparation, such as missing values imputation and transformation, is the first step in any data analysis and requires crucial attention. Particularly, analysis of metabolites demands more preparation since those small compounds have recently been measurable in large scales with mass spectrometry techniques.
arxiv  

HPDL Variant Type Correlates With Clinical Disease Onset and Severity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic paraplegia. HPDL converts 4‐hydroxyphenylpyruvate acid (4‐HPPA) into 4‐hydroxymandelate (4‐HMA),
Eun Hye Lee, Olivia Kim‐Mcmanus, Jennifer H. Yang, Richard Haas, Maha S. Zaki, Ghada M. H. Abdel‐Salam, Yuji Nakamura, Mohamed S. Abdel‐Hamind, Darius Ebrahimi‐Fakhari, Julian E. Alecu, Nicola Brunetti‐Pierri, Varunvenkat M. Srinivasan, Vykuntaraju K. Gowda, Stephanie Gross, Yasemin Alanay, Paria Najarzadeh Totbati, Manya Yadavilli, Liana Friedman, Naomi Meave Ojeda, Joseph G. Gleeson   +19 more
wiley   +1 more source

4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation

Drug Design, Development and Therapy, 2020
Yang Li,1 Xing Chen,1 Hua Zhang,1 Jie Xiao,2 Chuanlei Yang,2 Weiqiang Chen,1 Zhanjie Wei,3 Xinzhong Chen,1 Jinping Liu4 1Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan ...
Li Y, Chen X, Zhang H, Xiao J, Yang C, Chen W, Wei Z, Chen X, Liu J   +8 more
doaj  

Quantitative Studies on Human Urinary Metabolites of Tryptophan as Affected by Isoniazid and Deoxypyridoxine1 [PDF]

, 1957
J. M. Price, R. R. Brown, Frank C. Larson   +2 more
openalex   +1 more source

Identification of essential metabolites in metabolite networks

, 2012
Metabolite essentiality is an important topic in systems biology and as such there has been increased focus on their prediction in metabolic networks. Specifically, two related questions have become the focus of this field: how do we decrease the amount of gene knock-out workloads and is it possible to predict essential metabolites in different growth ...
openaire   +2 more sources

Elegant Metabolite Biosynthesis

Chemistry & Biology, 2011
Hormaomycin, an NRPS-produced bacterial metabolite involved in microbial signaling, possesses several remarkable structural features. The study by Höfer et al. (2011) employed a range of methodologies to explore and ultimately understand the elaborate biosynthesis of this complex natural product.
Adam C. Jones, Emily A. Monroe, William H. Gerwick   +2 more
openaire   +3 more sources

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source